Mouse models of pancreatic cancer: The fur is finally flying!

Steven D. Leach

Research output: Contribution to journalReview articlepeer-review

Abstract

Pancreatic cancer remains one of the most lethal of all human malignancies. Until recently, preclinical studies have been hampered by the absence of mouse models faithfully recapitulating critical elements of the human disease. However, recent months have witnessed a flurry of activity with respect to prospective mouse models. This progress now allows the evaluation of novel strategies for early detection, chemoprevention, and therapy and also provides new insights regarding the potential for differentiated and undifferentiated cell types to act as cells of origin for pancreatic ductal adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalCancer cell
Volume5
Issue number1
DOIs
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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