TY - JOUR
T1 - Mouse models of gene-environment interactions in schizophrenia
AU - Kannan, Geetha
AU - Sawa, Akira
AU - Pletnikov, Mikhail V.
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Gene-environment interactions (GEIs) likely play significant roles in the pathogenesis of schizophrenia and underlie differences in pathological, behavioral, and clinical presentations of the disease. Findings from epidemiology and psychiatric genetics have assisted in the generation of animal models of GEI relevant to schizophrenia. These models may provide a foundation for elucidating the molecular, cellular, and circuitry mechanisms that mediate GEI in schizophrenia. Here we critically review current mouse models of GEI related to schizophrenia, describe directions for their improvement, and propose endophenotypes to provide a more tangible basis for molecular studies of pathways of GEI and facilitate the identification of novel therapeutic targets.
AB - Gene-environment interactions (GEIs) likely play significant roles in the pathogenesis of schizophrenia and underlie differences in pathological, behavioral, and clinical presentations of the disease. Findings from epidemiology and psychiatric genetics have assisted in the generation of animal models of GEI relevant to schizophrenia. These models may provide a foundation for elucidating the molecular, cellular, and circuitry mechanisms that mediate GEI in schizophrenia. Here we critically review current mouse models of GEI related to schizophrenia, describe directions for their improvement, and propose endophenotypes to provide a more tangible basis for molecular studies of pathways of GEI and facilitate the identification of novel therapeutic targets.
KW - Animal models
KW - Endophenotypes
KW - Gene-environment interaction
KW - Schizophrenia
KW - Translational neuroscience
UR - http://www.scopus.com/inward/record.url?scp=84879782139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879782139&partnerID=8YFLogxK
U2 - 10.1016/j.nbd.2013.05.012
DO - 10.1016/j.nbd.2013.05.012
M3 - Review article
C2 - 23748077
AN - SCOPUS:84879782139
VL - 57
SP - 5
EP - 11
JO - Neurobiology of Disease
JF - Neurobiology of Disease
SN - 0969-9961
ER -