Mouse models of gene-environment interactions in schizophrenia

Geetha Kannan, Akira Sawa, Mikhail V. Pletnikov

Research output: Contribution to journalReview articlepeer-review

Abstract

Gene-environment interactions (GEIs) likely play significant roles in the pathogenesis of schizophrenia and underlie differences in pathological, behavioral, and clinical presentations of the disease. Findings from epidemiology and psychiatric genetics have assisted in the generation of animal models of GEI relevant to schizophrenia. These models may provide a foundation for elucidating the molecular, cellular, and circuitry mechanisms that mediate GEI in schizophrenia. Here we critically review current mouse models of GEI related to schizophrenia, describe directions for their improvement, and propose endophenotypes to provide a more tangible basis for molecular studies of pathways of GEI and facilitate the identification of novel therapeutic targets.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalNeurobiology of Disease
Volume57
DOIs
StatePublished - Sep 1 2013

Keywords

  • Animal models
  • Endophenotypes
  • Gene-environment interaction
  • Schizophrenia
  • Translational neuroscience

ASJC Scopus subject areas

  • Neurology

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