Mouse Models of Alzheimer's Disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transgenic mouse models of Alzheimer's disease (AD) have contributed significantly to our understanding of the pathophysiology of AD. Most models express either or both of the two major pathological changes seen in AD, amyloid plaques and neurofibrillary tangles. In other models, expression of the transgene of interest is controlled by an external control, or deleted from a selected locus. These models are essential tools for investigating biological mechanisms and assessing potential treatments for AD, and continue to make significant contribution towards further understanding of AD.

Original languageEnglish (US)
Title of host publicationPrinciples and Practice of Geriatric Psychiatry
Subtitle of host publicationThird Edition
PublisherJohn Wiley and Sons
Pages252-256
Number of pages5
ISBN (Print)9780470747230
DOIs
StatePublished - Dec 2 2010

Keywords

  • Alzheimer's disease
  • Amyloid
  • Neurofibrillary tangle
  • Tau
  • Transgenic mouse model

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Oh, E., Lyketsos, C., & Wong, P. (2010). Mouse Models of Alzheimer's Disease. In Principles and Practice of Geriatric Psychiatry: Third Edition (pp. 252-256). John Wiley and Sons. https://doi.org/10.1002/9780470669600.ch44