TY - JOUR
T1 - Mouse models of alopecia
T2 - Identifying structural genes that are baldly needed
AU - Tong, Xuemei
AU - Coulombe, Pierre A.
N1 - Funding Information:
Work in our laboratory is supported by grants AR42047 and AR44232 from the National Institute of Musculoskeletal, Arthritis and Skin Diseases.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - The mature hair follicle undergoes a unique developmental cycle, in which phases of growth are interspersed with phases of involution and rest. The main effectors of this cycle are skin epithelial stem cells that reside in a specialized compartment of the follicle. Defects in this cycle, or in the structure of the hair produced, often result in alopecia (partial or complete hair loss), a condition that affects a significant fraction of the population. Here we discuss transgenic mouse models that exhibit alopecia as a primary phenotype, resulting from the inactivation of genes encoding structural proteins.
AB - The mature hair follicle undergoes a unique developmental cycle, in which phases of growth are interspersed with phases of involution and rest. The main effectors of this cycle are skin epithelial stem cells that reside in a specialized compartment of the follicle. Defects in this cycle, or in the structure of the hair produced, often result in alopecia (partial or complete hair loss), a condition that affects a significant fraction of the population. Here we discuss transgenic mouse models that exhibit alopecia as a primary phenotype, resulting from the inactivation of genes encoding structural proteins.
UR - http://www.scopus.com/inward/record.url?scp=0037293446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037293446&partnerID=8YFLogxK
U2 - 10.1016/S1471-4914(02)00025-4
DO - 10.1016/S1471-4914(02)00025-4
M3 - Review article
C2 - 12615042
AN - SCOPUS:0037293446
SN - 1471-4914
VL - 9
SP - 79
EP - 84
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 2
ER -