Mouse models of alopecia: Identifying structural genes that are baldly needed

Xuemei Tong, Pierre A. Coulombe

Research output: Contribution to journalReview articlepeer-review

Abstract

The mature hair follicle undergoes a unique developmental cycle, in which phases of growth are interspersed with phases of involution and rest. The main effectors of this cycle are skin epithelial stem cells that reside in a specialized compartment of the follicle. Defects in this cycle, or in the structure of the hair produced, often result in alopecia (partial or complete hair loss), a condition that affects a significant fraction of the population. Here we discuss transgenic mouse models that exhibit alopecia as a primary phenotype, resulting from the inactivation of genes encoding structural proteins.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalTrends in Molecular Medicine
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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