Mouse models for studying genetic influences on factors determining smoking cessation success in humans

F. Scott Hall, Athina Markou, Edward D. Levin, George R. Uhl

Research output: Contribution to journalArticlepeer-review

Abstract

Humans differ in their ability to quit using addictive substances, including nicotine, the major psychoactive ingredient in tobacco. For tobacco smoking, a substantial body of evidence, largely derived from twin studies, indicates that approximately half of these individual differences in ability to quit are heritable genetic influences that likely overlap with those for other addictive substances. Both twin and molecular genetic studies support overlapping influences on nicotine addiction vulnerability and smoking cessation success, although there is little formal analysis of the twin data that support this important point. None of the current datasets provides clarity concerning which heritable factors might provide robust dimensions around which individuals differ in ability to quit smoking. One approach to this problem is to test mice with genetic variations in genes that contain human variants that alter quit success. This review considers which features of quit success should be included in a comprehensive approach to elucidate the genetics of quit success, and how those features may be modeled in mice.

Original languageEnglish (US)
Pages (from-to)39-70
Number of pages32
JournalAnnals of the New York Academy of Sciences
Volume1248
Issue number1
DOIs
StatePublished - Feb 2012
Externally publishedYes

Keywords

  • Genetics
  • Nicotine
  • Quit success
  • Smoking cessation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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