Mouse models for actinic keratoses

Justin Choi; Cameron E. West; Youkyung S. Roh; Nishadh Sutaria; Shawn G. Kwatra; Madan M. Kwatra

doi:10.1016/j.vascn.2021.107071

Mouse models for actinic keratoses

Justin Choi, Cameron E. West, Youkyung S. Roh, Nishadh Sutaria, Shawn G. Kwatra, Madan M. Kwatra

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Actinic keratoses (AKs) represent a premalignant skin condition due to chronic sun damage that dramatically increases in prevalence in the aging population. Currently, animal models of AKs utilize photocarcinogenesis, chemical carcinogens, or targeted gene modulation, and each method possesses unique strengths and weaknesses. Models using photodamage most comprehensively describe methods for preferentially selecting AK lesions, while replicating the pathogenesis of AKs with greater fidelity than models utilizing other carcinogenic methods. The following review of current murine models of AKs will aid in the selection of mouse models appropriate for future in vivo studies to test the efficacy of novel therapeutic agents for the treatment of AKs.

Original language	English (US)
Article number	107071
Journal	Journal of Pharmacological and Toxicological Methods
Volume	110
DOIs	https://doi.org/10.1016/j.vascn.2021.107071
State	Published - Jul 1 2021

Keywords

Actinic keratosis
DMBA/TPA
Mouse model
Skin cancer
Squamous cell carcinoma
UVB

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/j.vascn.2021.107071

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@article{72e50fb2a2da4631b709b6860c8f1002,

title = "Mouse models for actinic keratoses",

abstract = "Actinic keratoses (AKs) represent a premalignant skin condition due to chronic sun damage that dramatically increases in prevalence in the aging population. Currently, animal models of AKs utilize photocarcinogenesis, chemical carcinogens, or targeted gene modulation, and each method possesses unique strengths and weaknesses. Models using photodamage most comprehensively describe methods for preferentially selecting AK lesions, while replicating the pathogenesis of AKs with greater fidelity than models utilizing other carcinogenic methods. The following review of current murine models of AKs will aid in the selection of mouse models appropriate for future in vivo studies to test the efficacy of novel therapeutic agents for the treatment of AKs.",

keywords = "Actinic keratosis, DMBA/TPA, Mouse model, Skin cancer, Squamous cell carcinoma, UVB",

author = "Justin Choi and West, {Cameron E.} and Roh, {Youkyung S.} and Nishadh Sutaria and Kwatra, {Shawn G.} and Kwatra, {Madan M.}",

note = "Funding Information: SGK is an advisory board member for Genzada Pharmaceuticals and Castle Biosciences and is the recipient of a Dermatology Foundation Career Development Award. MMK has received grant funding from Genzada Pharmaeuticals. CEW serves on the Board of Directors and is a former employee of Genzada Pharmaceuticals. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = jul,

day = "1",

doi = "10.1016/j.vascn.2021.107071",

language = "English (US)",

volume = "110",

journal = "Journal of Pharmacological and Toxicological Methods",

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TY - JOUR

T1 - Mouse models for actinic keratoses

AU - Choi, Justin

AU - West, Cameron E.

AU - Roh, Youkyung S.

AU - Sutaria, Nishadh

AU - Kwatra, Shawn G.

AU - Kwatra, Madan M.

N1 - Funding Information: SGK is an advisory board member for Genzada Pharmaceuticals and Castle Biosciences and is the recipient of a Dermatology Foundation Career Development Award. MMK has received grant funding from Genzada Pharmaeuticals. CEW serves on the Board of Directors and is a former employee of Genzada Pharmaceuticals. Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Actinic keratoses (AKs) represent a premalignant skin condition due to chronic sun damage that dramatically increases in prevalence in the aging population. Currently, animal models of AKs utilize photocarcinogenesis, chemical carcinogens, or targeted gene modulation, and each method possesses unique strengths and weaknesses. Models using photodamage most comprehensively describe methods for preferentially selecting AK lesions, while replicating the pathogenesis of AKs with greater fidelity than models utilizing other carcinogenic methods. The following review of current murine models of AKs will aid in the selection of mouse models appropriate for future in vivo studies to test the efficacy of novel therapeutic agents for the treatment of AKs.

AB - Actinic keratoses (AKs) represent a premalignant skin condition due to chronic sun damage that dramatically increases in prevalence in the aging population. Currently, animal models of AKs utilize photocarcinogenesis, chemical carcinogens, or targeted gene modulation, and each method possesses unique strengths and weaknesses. Models using photodamage most comprehensively describe methods for preferentially selecting AK lesions, while replicating the pathogenesis of AKs with greater fidelity than models utilizing other carcinogenic methods. The following review of current murine models of AKs will aid in the selection of mouse models appropriate for future in vivo studies to test the efficacy of novel therapeutic agents for the treatment of AKs.

KW - Actinic keratosis

KW - DMBA/TPA

KW - Mouse model

KW - Skin cancer

KW - Squamous cell carcinoma

KW - UVB

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U2 - 10.1016/j.vascn.2021.107071

DO - 10.1016/j.vascn.2021.107071

M3 - Review article

C2 - 33933627

AN - SCOPUS:85105347060

SN - 1056-8719

VL - 110

JO - Journal of Pharmacological and Toxicological Methods

JF - Journal of Pharmacological and Toxicological Methods

M1 - 107071

ER -

Mouse models for actinic keratoses

Abstract

Keywords

ASJC Scopus subject areas

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