Mouse models for actinic keratoses

Justin Choi, Cameron E. West, Youkyung S. Roh, Nishadh Sutaria, Shawn G. Kwatra, Madan M. Kwatra

Research output: Contribution to journalReview articlepeer-review


Actinic keratoses (AKs) represent a premalignant skin condition due to chronic sun damage that dramatically increases in prevalence in the aging population. Currently, animal models of AKs utilize photocarcinogenesis, chemical carcinogens, or targeted gene modulation, and each method possesses unique strengths and weaknesses. Models using photodamage most comprehensively describe methods for preferentially selecting AK lesions, while replicating the pathogenesis of AKs with greater fidelity than models utilizing other carcinogenic methods. The following review of current murine models of AKs will aid in the selection of mouse models appropriate for future in vivo studies to test the efficacy of novel therapeutic agents for the treatment of AKs.

Original languageEnglish (US)
Article number107071
JournalJournal of Pharmacological and Toxicological Methods
StatePublished - Jul 1 2021


  • Actinic keratosis
  • Mouse model
  • Skin cancer
  • Squamous cell carcinoma
  • UVB

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


Dive into the research topics of 'Mouse models for actinic keratoses'. Together they form a unique fingerprint.

Cite this