Mouse models and genetics of immunosenescence

Qing Yu, Jyoti Misra Sen, Dennis Taub

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Age-related changes in the immune system result in deterioration in the ability of elderly human beings to develop immunity after vaccination and to respond to infections. Thereby the quality of longer lifespan enjoyed by modern man is significantly compromised. Furthermore, higher mortality in the elderly from infections, autoimmune disease and cancer is associated with decline in the immune function. The use of rodent models has yielded critical knowledge of mechanisms by which immune cells develop and function. In this chapter, we focus on several mouse models that have provided significant data on the changes in immune system with advancing age. A greater understanding of many of the age-related changes in immune function, recently defined as immunosenescence, may provide important insight into the development of clinical strategies and interventions for the maintenance of adequate immune system as human beings age.

Original languageEnglish (US)
Title of host publicationHandbook on Immunosenescence: Basic Understanding and Clinical Applications
PublisherSpringer Netherlands
Pages63-85
Number of pages23
ISBN (Print)9781402090639, 9781402090622
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Immune aging
  • Immune system
  • Immunosenescence
  • Mouse models
  • Thymic involution

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Yu, Q., Sen, J. M., & Taub, D. (2009). Mouse models and genetics of immunosenescence. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications (pp. 63-85). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9063-9-3