Mouse model of intrauterine inflammation: Sex-specific differences in long-term neurologic and immune sequelae

Tahani Dada, Jason M. Rosenzweig, Mofeedah Al Shammary, Wance Firdaus, Shorouq Al Rebh, Talaibek Borbiev, Aylin Tekes, Jiangyang Zhang, Eman Alqahtani, Susumu Mori, Mikhail V. Pletnikov, Michael V. Johnston, Irina Burd

Research output: Contribution to journalArticle

Abstract

Preterm infants, especially those that are exposed to prenatal intrauterine infection or inflammation, are at a major risk for adverse neurological outcomes, including cognitive, motor and behavioral disabilities. We have previously shown in a mouse model that there is an acute fetal brain insult associated with intrauterine inflammation. The objectives of this study were: (1) to elucidate long-term (into adolescence and adulthood) neurological outcomes by assessing neurobehavioral development, MRI, immunohistochemistry and flow cytometry of cells of immune origin and (2) to determine whether there are any sex-specific differences in brain development associated with intrauterine inflammation. Our results have shown that prenatal exposure appeared to lead to changes in MRI and behavior patterns throughout the neonatal period and during adulthood. Furthermore, we observed chronic brain inflammation in the offspring, with persistence of microglial activation and increased numbers of macrophages in the brain, ultimately resulting in neuronal loss. Moreover, our study highlights the sex-specific differences in long-term sequelae. This study, while extending the growing literature of adverse neurologic outcomes following exposure to inflammation during early development, presents novel findings in the context of intrauterine inflammation.

Original languageEnglish (US)
Pages (from-to)142-150
Number of pages9
JournalBrain, Behavior, and Immunity
Volume38
DOIs
StatePublished - May 2014

Keywords

  • Behavior
  • Brain damage
  • Intrauterine inflammation
  • Lipopolysaccharide
  • MRI
  • Mouse model
  • Preterm birth

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

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