Mouse Hepatitis Virus-Induced Recurrent Demyelination: A Preliminary Report

Robert M. Herndon; Diane E. Griffin; Ursula Mccormick; Leslie P. Weiner

doi:10.1001/archneur.1975.00490430054008

Mouse Hepatitis Virus-Induced Recurrent Demyelination: A Preliminary Report

Robert M. Herndon, Diane E. Griffin, Ursula Mccormick, Leslie P. Weiner

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

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Abstract

Four-week-old BALB/c mice inoculated intracerebrally with the JHM strain of mouse hepatitis virus developed an acute demyelinating disease followed by apparent recovery with remyelination. When surviving mice were examined 16 months later, small areas of active demyelination were still present. This is the first reported example, to our knowledge, of an experimental viral infection in which acute demyelination with recovery is followed by persisting or recurring demyelination.

Original language	English (US)
Pages (from-to)	32-35
Number of pages	4
Journal	Archives of neurology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1001/archneur.1975.00490430054008
State	Published - Jan 1975

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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abstract = "Four-week-old BALB/c mice inoculated intracerebrally with the JHM strain of mouse hepatitis virus developed an acute demyelinating disease followed by apparent recovery with remyelination. When surviving mice were examined 16 months later, small areas of active demyelination were still present. This is the first reported example, to our knowledge, of an experimental viral infection in which acute demyelination with recovery is followed by persisting or recurring demyelination.",

author = "Herndon, {Robert M.} and Griffin, {Diane E.} and Ursula Mccormick and Weiner, {Leslie P.}",

year = "1975",

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AU - Griffin, Diane E.

AU - Mccormick, Ursula

AU - Weiner, Leslie P.

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N2 - Four-week-old BALB/c mice inoculated intracerebrally with the JHM strain of mouse hepatitis virus developed an acute demyelinating disease followed by apparent recovery with remyelination. When surviving mice were examined 16 months later, small areas of active demyelination were still present. This is the first reported example, to our knowledge, of an experimental viral infection in which acute demyelination with recovery is followed by persisting or recurring demyelination.

AB - Four-week-old BALB/c mice inoculated intracerebrally with the JHM strain of mouse hepatitis virus developed an acute demyelinating disease followed by apparent recovery with remyelination. When surviving mice were examined 16 months later, small areas of active demyelination were still present. This is the first reported example, to our knowledge, of an experimental viral infection in which acute demyelination with recovery is followed by persisting or recurring demyelination.

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Mouse Hepatitis Virus-Induced Recurrent Demyelination: A Preliminary Report

Abstract

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