Mouse Hepatitis Virus-Induced Recurrent Demyelination: A Preliminary Report

Robert M. Herndon, Diane E. Griffin, Ursula Mccormick, Leslie P. Weiner

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Four-week-old BALB/c mice inoculated intracerebrally with the JHM strain of mouse hepatitis virus developed an acute demyelinating disease followed by apparent recovery with remyelination. When surviving mice were examined 16 months later, small areas of active demyelination were still present. This is the first reported example, to our knowledge, of an experimental viral infection in which acute demyelination with recovery is followed by persisting or recurring demyelination.

Original languageEnglish (US)
Pages (from-to)32-35
Number of pages4
JournalArchives of neurology
Issue number1
StatePublished - Jan 1975

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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