Mouse chromosome fragility

M. M. Sanz, E. C. Jenkins, W. T. Brown, M. T. Davisson, M. J. Kevin, T. H. Roderick, Wayne P Silverman, H. M. Wisniewski

Research output: Contribution to journalArticle

Abstract

When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

Original languageEnglish (US)
Pages (from-to)491-509
Number of pages19
JournalAmerican Journal of Medical Genetics
Volume23
Issue number1-2
StatePublished - 1986
Externally publishedYes

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Chromosome Fragility
Chromosome Breakage
Inbred Strains Mice
Animal Models
Fibroblasts
Genome

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Sanz, M. M., Jenkins, E. C., Brown, W. T., Davisson, M. T., Kevin, M. J., Roderick, T. H., ... Wisniewski, H. M. (1986). Mouse chromosome fragility. American Journal of Medical Genetics, 23(1-2), 491-509.

Mouse chromosome fragility. / Sanz, M. M.; Jenkins, E. C.; Brown, W. T.; Davisson, M. T.; Kevin, M. J.; Roderick, T. H.; Silverman, Wayne P; Wisniewski, H. M.

In: American Journal of Medical Genetics, Vol. 23, No. 1-2, 1986, p. 491-509.

Research output: Contribution to journalArticle

Sanz, MM, Jenkins, EC, Brown, WT, Davisson, MT, Kevin, MJ, Roderick, TH, Silverman, WP & Wisniewski, HM 1986, 'Mouse chromosome fragility', American Journal of Medical Genetics, vol. 23, no. 1-2, pp. 491-509.
Sanz MM, Jenkins EC, Brown WT, Davisson MT, Kevin MJ, Roderick TH et al. Mouse chromosome fragility. American Journal of Medical Genetics. 1986;23(1-2):491-509.
Sanz, M. M. ; Jenkins, E. C. ; Brown, W. T. ; Davisson, M. T. ; Kevin, M. J. ; Roderick, T. H. ; Silverman, Wayne P ; Wisniewski, H. M. / Mouse chromosome fragility. In: American Journal of Medical Genetics. 1986 ; Vol. 23, No. 1-2. pp. 491-509.
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AU - Roderick, T. H.

AU - Silverman, Wayne P

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