Mouse chromosome fragility

M. M. Sanz, E. C. Jenkins, W. T. Brown, M. T. Davisson, M. J. Kevin, T. H. Roderick, W. P. Silverman, H. M. Wisniewski

Research output: Contribution to journalArticlepeer-review

Abstract

When cultures of fibroblast-like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5-fluorodeoxyridine (FUdR), non-random strain-specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain-specific fragile sites were identified in strain RBC/Dn at G-band 15A2, and at G-band 19B in strain AEJ/GnRk. Constitutive fragile sites at G-bands 12A2 and 18A2 were identified in both strains. A strain-specific marker at G-band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

Original languageEnglish (US)
Pages (from-to)491-509
Number of pages19
JournalAmerican journal of medical genetics
Volume23
Issue number1-2
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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