Mouse allergen, lung function, and atopy in Puerto Rican children

Erick Forno, Michelle M. Cloutier, Soma Datta, Kathryn Paul, Jody Sylvia, Deanna Calvert, Sherell Thornton-Thompson, Dorothy B. Wakefield, John Brehm, Robert G. Hamilton, María Alvarez, Angel Colón-Semidey, Edna Acosta-Pérez, Glorisa Canino, Juan C. Celedón

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Abstract

Objective: To examine the relation between mouse allergen exposure and asthma in Puerto Rican children. Methods: Mus m 1, Der p 1, Bla g 2, and Fel d 1 allergens were measured in dust samples from homes of Puerto Rican children with (cases) and without (controls) asthma in Hartford, CT (n = 449) and San Juan (SJ), Puerto Rico (n = 678). Linear or logistic regression was used for the multivariate analysis of mouse allergen (Mus m 1) and lung function (FEV1 and FEV1/FVC) and allergy (total IgE and skin test reactivity (STR) to ≥1 allergen) measures. Results: Homes in SJ had lower mouse allergen levels than those in Hartford. In multivariate analyses, mouse allergen was associated with higher FEV1 in cases in Hartford (+70.6 ml, 95% confidence interval (CI) = 8.6-132.7 ml, P = 0.03) and SJ (+45.1 ml, 95% CI = -0.5 to 90.6 ml, P = 0.05). In multivariate analyses of controls, mouse allergen was inversely associated with STR to ≥1 allergen in non-sensitized children (odds ratio [OR] for each log-unit increment in Mus m 1 = 0.7, 95% CI = 0.5-0.9, P<0.01). In a multivariate analysis including all children at both study sites, each log-increment in mouse allergen was positively associated with FEV1 (+28.3 ml, 95% CI = 1.4-55.2 ml, P = 0.04) and inversely associated with STR to ≥1 allergen (OR for each log-unit increment in Mus m 1 = 0.8, 95% CI = 0.6-0.9, P<0.01). Conclusions: Mouse allergen is associated with a higher FEV1 and lower odds of STR to ≥1 allergen in Puerto Rican children. This may be explained by the allergen itself or correlated microbial exposures.

Original languageEnglish (US)
Article numbere40383
JournalPloS one
Volume7
Issue number7
DOIs
StatePublished - Jul 16 2012

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Forno, E., Cloutier, M. M., Datta, S., Paul, K., Sylvia, J., Calvert, D., Thornton-Thompson, S., Wakefield, D. B., Brehm, J., Hamilton, R. G., Alvarez, M., Colón-Semidey, A., Acosta-Pérez, E., Canino, G., & Celedón, J. C. (2012). Mouse allergen, lung function, and atopy in Puerto Rican children. PloS one, 7(7), [e40383]. https://doi.org/10.1371/journal.pone.0040383