Mouse allergen is the major allergen of public health relevance in Baltimore City

Sharon K. Ahluwalia, Roger Peng, Patrick N Breysse, Gregory B Diette, Jean Curtin-Brosnan, Charles Aloe, Elizabeth C. Matsui

Research output: Contribution to journalArticle

Abstract

Background: Cockroach and mouse allergens have both been implicated as causes in inner-city asthma morbidity in multicenter studies, but whether both allergens are clinically relevant within specific inner-city communities is unclear. Objective: Our study aimed to identify relevant allergens in Baltimore City. Methods: One hundred forty-four children (5-17 years old) with asthma underwent skin prick tests at baseline and had clinical data collected at baseline and 3, 6, 9, and 12 months. Home settled dust samples were collected at the same time points for quantification of indoor allergens. Participants were grouped based on their sensitization and exposure status to each allergen. All analyses were adjusted for age, sex, and serum total IgE level. Results: Forty-one percent were mouse sensitized/exposed, and 41% were cockroach sensitized/exposed based on bedroom floor exposure data. Mouse sensitization/exposure was associated with acute care visits, decreased FEV 1/forced vital capacity percentage values, fraction of exhaled nitric oxide levels, and bronchodilator reversibility. Cockroach sensitization/ exposure was only associated with acute care visits and bronchodilator reversibility when exposure was defined by using bedroom floor allergen levels. Mouse-specific IgE levels were associated with poor asthma health across a range of outcomes, whereas cockroach-specific IgE levels were not. The relationships between asthma outcomes and mouse allergen were independent of cockroach allergen. Although sensitization/exposure to both mouse and cockroach was generally associated with worse asthma, mouse sensitization/exposure was the primary contributor to these relationships. Conclusions: In a community with high levels of both mouse and cockroach allergens, mouse allergen appears to be more strongly and consistently associated with poor asthma outcomes than cockroach allergen. Community-level asthma interventions in Baltimore should prioritize reducing mouse allergen exposure.

Original languageEnglish (US)
JournalThe Journal of Allergy and Clinical Immunology
Volume132
Issue number4
DOIs
StatePublished - Oct 2013

Fingerprint

Baltimore
Allergens
Cockroaches
Public Health
Asthma
Immunoglobulin E
Bronchodilator Agents
Vital Capacity
Skin Tests
Dust
Multicenter Studies
Nitric Oxide

Keywords

  • childhood asthma
  • cockroach allergen
  • indoor allergens
  • Inner-city asthma
  • mouse allergen

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Mouse allergen is the major allergen of public health relevance in Baltimore City. / Ahluwalia, Sharon K.; Peng, Roger; Breysse, Patrick N; Diette, Gregory B; Curtin-Brosnan, Jean; Aloe, Charles; Matsui, Elizabeth C.

In: The Journal of Allergy and Clinical Immunology, Vol. 132, No. 4, 10.2013.

Research output: Contribution to journalArticle

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AU - Peng, Roger

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AU - Aloe, Charles

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AB - Background: Cockroach and mouse allergens have both been implicated as causes in inner-city asthma morbidity in multicenter studies, but whether both allergens are clinically relevant within specific inner-city communities is unclear. Objective: Our study aimed to identify relevant allergens in Baltimore City. Methods: One hundred forty-four children (5-17 years old) with asthma underwent skin prick tests at baseline and had clinical data collected at baseline and 3, 6, 9, and 12 months. Home settled dust samples were collected at the same time points for quantification of indoor allergens. Participants were grouped based on their sensitization and exposure status to each allergen. All analyses were adjusted for age, sex, and serum total IgE level. Results: Forty-one percent were mouse sensitized/exposed, and 41% were cockroach sensitized/exposed based on bedroom floor exposure data. Mouse sensitization/exposure was associated with acute care visits, decreased FEV 1/forced vital capacity percentage values, fraction of exhaled nitric oxide levels, and bronchodilator reversibility. Cockroach sensitization/ exposure was only associated with acute care visits and bronchodilator reversibility when exposure was defined by using bedroom floor allergen levels. Mouse-specific IgE levels were associated with poor asthma health across a range of outcomes, whereas cockroach-specific IgE levels were not. The relationships between asthma outcomes and mouse allergen were independent of cockroach allergen. Although sensitization/exposure to both mouse and cockroach was generally associated with worse asthma, mouse sensitization/exposure was the primary contributor to these relationships. Conclusions: In a community with high levels of both mouse and cockroach allergens, mouse allergen appears to be more strongly and consistently associated with poor asthma outcomes than cockroach allergen. Community-level asthma interventions in Baltimore should prioritize reducing mouse allergen exposure.

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KW - Inner-city asthma

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