Motor overflow in children with attention-deficit/hyperactivity disorder is associated with decreased extent of neural activation in the motor cortex

Andrew Gaddis, Keri S. Rosch, Benjamin Dirlikov, Deana Crocetti, Lindsey MacNeil, Anita D. Barber, John Muschelli, Brian S Caffo, James J Pekar, Stewart H Mostofsky

Research output: Contribution to journalArticle

Abstract

Motor overflow is a developmental phenomenon that typically disappears by late childhood. Abnormal persistence of motor overflow is often present in children with attention-deficit/hyperactivity disorder (ADHD). This study employed functional magnetic resonance imaging (fMRI) during a finger-sequencing task to examine whether excessive motor overflow in children with ADHD is associated with decreased extent of motor circuit activation. Thirty-four right-handed children (18 typically developing controls, 16 ADHD) completed fMRI while performing a finger-sequencing task. Motor overflow was evaluated during a finger-sequencing task and a motor examination (the PANESS) performed outside the scanner. Diagnostic differences in behavioral measures of overflow and extent of activation in the contralateral and ipsilateral motor network ROIs were examined, along with correlations between overflow and extent of activation. Children with ADHD demonstrated greater overflow and lesser extent of activation in left primary motor cortex (BA4) and bilateral premotor cortex (BA6) and supplementary motor area (SMA) during right-hand finger-sequencing compared to controls. Decreased extent of primary motor and premotor activation correlated with increased hand-related overflow movements in children with ADHD but not controls. These findings suggest that overflow movements in children with ADHD may reflect decreased recruitment of neural circuitry involved in active inhibition of homologous motor circuitry unnecessary to task execution.

Original languageEnglish (US)
Pages (from-to)488-495
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume233
Issue number3
DOIs
StatePublished - 2015

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Motor Cortex
Attention Deficit Disorder with Hyperactivity
Fingers
Hand
Magnetic Resonance Imaging

Keywords

  • Finger-sequencing
  • fMRI
  • Inhibition
  • PANESS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Motor overflow in children with attention-deficit/hyperactivity disorder is associated with decreased extent of neural activation in the motor cortex. / Gaddis, Andrew; Rosch, Keri S.; Dirlikov, Benjamin; Crocetti, Deana; MacNeil, Lindsey; Barber, Anita D.; Muschelli, John; Caffo, Brian S; Pekar, James J; Mostofsky, Stewart H.

In: Psychiatry Research - Neuroimaging, Vol. 233, No. 3, 2015, p. 488-495.

Research output: Contribution to journalArticle

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