TY - JOUR
T1 - Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons
AU - Sockanathan, Shanthini
AU - Jessell, Thomas M.
N1 - Funding Information:
We thank S. Kaplan for technical help; S. Pfaff for the chick RALDH2 PCR fragment; G. Eichele for TTNPB and advice on retinoid metabolism; R. Heyman (Ligand Pharmaceuticals) for RAR and RXR agonists and antagonists; and S. Morton for advice on antibody purification. We are grateful to T. Perlmann, L. Solomin, and R. Krumlauf for communication of results prior to publication; to T. Edlund for advice; and to S. Arber, R. Axel, J. Briscoe, J. Ericson, T. Perlmann, and L. Solomin for comments on the manuscript. K. MacArthur and I. Schieren provided expert help in the preparation of the manuscript. This work was supported by the ALS Association and NIH. T. M. J. is an investigator of the Howard Hughes Medical Institute.
PY - 1998/8/21
Y1 - 1998/8/21
N2 - The diversification of neuronal cell types in the vertebrate central nervous system depends on inductive signals provided by local organizing cell groups of both neural and nonneural origin. The influence of signals provided by postmitotic neurons on the fate of neurons born at subsequent development stages, however, remains unclear. We provide evidence that a retinoid- mediated signal provided by one subset of early-born spinal motor neurons imposes a local variation in the number of motor neurons generated at different axial levels and also specifies the identity of a later-born subset of motor neurons. Thus, in the vertebrate central nervous system the distinct fates of late-born neurons may be acquired in response to signals provided by early-born neurons.
AB - The diversification of neuronal cell types in the vertebrate central nervous system depends on inductive signals provided by local organizing cell groups of both neural and nonneural origin. The influence of signals provided by postmitotic neurons on the fate of neurons born at subsequent development stages, however, remains unclear. We provide evidence that a retinoid- mediated signal provided by one subset of early-born spinal motor neurons imposes a local variation in the number of motor neurons generated at different axial levels and also specifies the identity of a later-born subset of motor neurons. Thus, in the vertebrate central nervous system the distinct fates of late-born neurons may be acquired in response to signals provided by early-born neurons.
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U2 - 10.1016/S0092-8674(00)81591-3
DO - 10.1016/S0092-8674(00)81591-3
M3 - Article
C2 - 9727493
AN - SCOPUS:0032555724
VL - 94
SP - 503
EP - 514
JO - Cell
JF - Cell
SN - 0092-8674
IS - 4
ER -