Motor neuron death in ALS: Programmed by astrocytes?

Sheila K. Pirooznia, Valina L. Dawson, Ted M. Dawson

Research output: Contribution to journalShort survey

Abstract

Motor neurons in ALS die via cell-autonomous and non-cell-autonomous mechanisms. Using adult human astrocytes and motor neurons, Re et al. (2014), in this issue of Neuron, discover that familial and sporadic ALS-derived human adult astrocytes secrete neurotoxic factors that selectively kill motor neurons through necroptosis, suggesting a new therapeutic avenue.

Original languageEnglish (US)
Pages (from-to)961-963
Number of pages3
JournalNeuron
Volume81
Issue number5
DOIs
StatePublished - Mar 5 2014

ASJC Scopus subject areas

  • Neuroscience(all)

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