TY - JOUR
T1 - Motor neuron death in ALS
T2 - Programmed by astrocytes?
AU - Pirooznia, Sheila K.
AU - Dawson, Valina L.
AU - Dawson, Ted M.
PY - 2014/3/5
Y1 - 2014/3/5
N2 - Motor neurons in ALS die via cell-autonomous and non-cell-autonomous mechanisms. Using adult human astrocytes and motor neurons, Re et al. (2014), in this issue of Neuron, discover that familial and sporadic ALS-derived human adult astrocytes secrete neurotoxic factors that selectively kill motor neurons through necroptosis, suggesting a new therapeutic avenue.
AB - Motor neurons in ALS die via cell-autonomous and non-cell-autonomous mechanisms. Using adult human astrocytes and motor neurons, Re et al. (2014), in this issue of Neuron, discover that familial and sporadic ALS-derived human adult astrocytes secrete neurotoxic factors that selectively kill motor neurons through necroptosis, suggesting a new therapeutic avenue.
UR - http://www.scopus.com/inward/record.url?scp=84895447564&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895447564&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2014.02.024
DO - 10.1016/j.neuron.2014.02.024
M3 - Short survey
C2 - 24607221
AN - SCOPUS:84895447564
SN - 0896-6273
VL - 81
SP - 961
EP - 963
JO - Neuron
JF - Neuron
IS - 5
ER -