Motor nerve regeneration across a conduit

Gedge D. Rosson, Eric H. Williams, A. Lee Dellon

Research output: Contribution to journalArticlepeer-review

Abstract

A 3-cm gap in the ulnar nerve at the elbow in a subhuman primate was the first model of nerve regeneration across a polyglycolic, bioab-sorbable conduit. When a prospective trial was begun in humans, the first clinically available bioabsorbable conduit, the Neurotube™,was utilized to reconstruct sensory nerves, but motor nerve injuries were not included. Thus, we sought to evaluate our patients with short-gap motor nerve injuries repaired with bioabsorbable conduits. We performed a retrospective chart review of all patients with bioabsorbable nerve conduit repair of short-gap motor nerve injuries over a 7-year period-six patients were identified. All patients had some return of motor function. Our case series, along with the nonhuman primate studies and other human reports, demonstrates that motor nerves will regenerate through bioabsorbable conduits and will reinnervate appropriate motor-target end-organs if they can reach them within an appropriate time frame for persistence of the motor-endplates.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalMicrosurgery
Volume29
Issue number2
DOIs
StatePublished - Mar 9 2009

ASJC Scopus subject areas

  • Surgery

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