Abstract
Tourette syndrome (TS) and primary complex motor stereotypies (CMS) are two relatively common, distinctly different movement disorders of childhood. Despite their frequency, the precise underlying pathophysiological mechanism(s) for tics and stereotypies remains unknown. Both are likely to involve cortical-striatal-thalamo-cortical (CSTC) pathways or their interconnecting brain regions. In recent studies, distinct, separate cortical-striatal pathways have been identified for goal-directed and habitual behavioral activity with important influences from structures, such as the hippocampus, amygdala, dorsolateral prefrontal cortex, cerebellum, ventral tegmental area, and substantia nigra pars compacta. Determining the specific site of abnormality within these circuits remains an active area of research. At the synaptic level, numerous neurotransmitters are involved in the transmission of messages through CSTC pathways, and many have been proposed as potential pathophysiological mechanisms. Which, if any, transmitter is the primary pathological factor in TS and primary CMS remains to be definitively determined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 22-31 |
| Number of pages | 10 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1304 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 2013 |
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Keywords
- Habits
- Motor control
- Motor stereotypies
- Tics
- Tourette
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
Motor control, habits, complex motor stereotypies, and Tourette syndrome. / Singer, Harvey.
In: Annals of the New York Academy of Sciences, Vol. 1304, No. 1, 11.2013, p. 22-31.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Motor control, habits, complex motor stereotypies, and Tourette syndrome
AU - Singer, Harvey
PY - 2013/11
Y1 - 2013/11
N2 - Tourette syndrome (TS) and primary complex motor stereotypies (CMS) are two relatively common, distinctly different movement disorders of childhood. Despite their frequency, the precise underlying pathophysiological mechanism(s) for tics and stereotypies remains unknown. Both are likely to involve cortical-striatal-thalamo-cortical (CSTC) pathways or their interconnecting brain regions. In recent studies, distinct, separate cortical-striatal pathways have been identified for goal-directed and habitual behavioral activity with important influences from structures, such as the hippocampus, amygdala, dorsolateral prefrontal cortex, cerebellum, ventral tegmental area, and substantia nigra pars compacta. Determining the specific site of abnormality within these circuits remains an active area of research. At the synaptic level, numerous neurotransmitters are involved in the transmission of messages through CSTC pathways, and many have been proposed as potential pathophysiological mechanisms. Which, if any, transmitter is the primary pathological factor in TS and primary CMS remains to be definitively determined.
AB - Tourette syndrome (TS) and primary complex motor stereotypies (CMS) are two relatively common, distinctly different movement disorders of childhood. Despite their frequency, the precise underlying pathophysiological mechanism(s) for tics and stereotypies remains unknown. Both are likely to involve cortical-striatal-thalamo-cortical (CSTC) pathways or their interconnecting brain regions. In recent studies, distinct, separate cortical-striatal pathways have been identified for goal-directed and habitual behavioral activity with important influences from structures, such as the hippocampus, amygdala, dorsolateral prefrontal cortex, cerebellum, ventral tegmental area, and substantia nigra pars compacta. Determining the specific site of abnormality within these circuits remains an active area of research. At the synaptic level, numerous neurotransmitters are involved in the transmission of messages through CSTC pathways, and many have been proposed as potential pathophysiological mechanisms. Which, if any, transmitter is the primary pathological factor in TS and primary CMS remains to be definitively determined.
KW - Habits
KW - Motor control
KW - Motor stereotypies
KW - Tics
KW - Tourette
UR - http://www.scopus.com/inward/record.url?scp=84888431259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888431259&partnerID=8YFLogxK
U2 - 10.1111/nyas.12281
DO - 10.1111/nyas.12281
M3 - Article
C2 - 24175737
AN - SCOPUS:84888431259
VL - 1304
SP - 22
EP - 31
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - 1
ER -