Motion-incorporated partial volume correction: Methodology and validation

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

With the advance in PET technology and especially scintillating detectors, spatial resolution in the order of 2 mm FWHM are becoming a reality, allowing a more in-depth exploration of complex organs such as the human brain. Subject movement during imaging has always been a factor contributing to image degradation, but is becoming a major limitation in the achievement of the full spatial resolution potential of modern scanners. We propose to demonstrate that the geometric transfer matrix (GTM) method which is a popular method used for partial volume correction (PVC) can be further extended to head movement correction (HMC) when it is associated with some means of head motion tracking (HMT), and is thereafter referred to as the GTM-HMC method. Computer simulations of arbitrary movements were carried out on in a single magnetic resonance image (MRI) volume that was segmented into various functional regions. Data were analyzed without any correction, after application of the GTM-PVC method alone, and after application of the new GTM-HMC method. Results indicate an excellent recovery capability of the new algorithm in the presence of small movements, with typical root-mean square error of less than 1% over the course of a 90-min study. In the presence of noise, the algorithm did not suffer from increased variance compared to when performing GTM-PVC alone. This method is expected to be of great interest since it can account for all detected movements, does not require the reconstruction of intermediate images with inferior statistics, nor is as computerintensive as event-driven movement correction methods.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
Pages2359-2361
Number of pages3
DOIs
StatePublished - Dec 1 2010
Event2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States
Duration: Oct 30 2010Nov 6 2010

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
CountryUnited States
CityKnoxville, TN
Period10/30/1011/6/10

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Rousset, O. G., Rahmim, A., & Wong, D. F. (2010). Motion-incorporated partial volume correction: Methodology and validation. In IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010 (pp. 2359-2361). [5874207] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2010.5874207