Mother-to-child transmission of HIV among women who chose not to exclusively breastfeed their infants in Pune, India

Amita Gupta, Nikhil Gupte, Jayagowri Sastry, Kapila E. Bharucha, Ramesh Bhosale, Poorva Kulkarni, Srikanth Tripathy, Uma Nayak, Mridula Phadke, Robert C. Bollinger

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background & objectives: The percentage of HIV cases attributed to mother-to-child transmission (MTCT) has increased several fold in recent years. No reports are available on HIV MTCT rates among HIV-infected choosing not be exclusively breastfeed their infants in India. We examined HIV MTCT rates among 41 Indian women in a prospective cohort who chose predominantly not to exclusively breastfeed. Methods: Of the 41 women, 27 (66%) received MTCT prophylaxis: 3 received short course zidovudine (AZT), 19 single-dose nevirapine (NVP), and 5 both AZT and NVP. Maternal HIV-I RNA levels (viral load) were measured at the time of delivery. Infants were tested for HIV-1 infection by PCR up to 11 times is first year of life and viral load was measured in PCR positive infants. Results: All infants received single dose NVP. Thirty two (76%) infants were exclusively formula-fed, 10 (24%) were mixed fed. Four infants we diagnosed with HIV infection for an overall 12-month transmission probability of 8 per cent [95 % confidence interval (CI) of 3.2 to 22.1%]. Restricting analysis to 31 women who exclusively formula-fed, only one (3.1%) transmission event occurred. The 41 HIV-infected women gave birth to 42 live-born infants. Interpretation & conclusion: Our data from a small cohort of HIV-infected women suggest that short-course AZT or single dose NVP are effective in reducing MTCT in an Indian setting. Larger studies are needed to assess HIV MTCT rates in India, but in this small study rates were comparable to that observed among women who chose not exclusively breastfeed in other resource-limited settings.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalIndian Journal of Medical Research
Issue number2
StatePublished - Aug 2007


  • HIV
  • India
  • Mother-to-child
  • Nevirapine
  • Non-breastfeeding
  • Prospective cohort
  • Transmission
  • Zidovudine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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