Mosquito transgenesis: what is the fitness cost?

Mauro T. Marrelli, Cristina K. Moreira, David Kelly, Luke Alphey, Marcelo Jacobs-Lorena

Research output: Contribution to journalArticle

Abstract

The generation of transgenic mosquitoes with a minimal fitness load is a prerequisite for the success of strategies for controlling mosquito-borne diseases using transgenic insects. It is important to assemble as much information as possible on this subject because realistic estimates of transgene fitness costs are essential for modeling and planning release strategies. Transgenic mosquitoes must have minimal fitness costs, because such costs would reduce the effectiveness of the genetic drive mechanisms that are used to introduce the transgenes into field mosquito populations. Several factors affect fitness of transgenic mosquitoes, including the potential negative effect of transgene products and insertional mutagenesis. Studies to assess fitness of transgenic mosquitoes in the field (as opposed to the laboratory) are still needed.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalTrends in Parasitology
Volume22
Issue number5
DOIs
StatePublished - May 2006

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Gene Transfer Techniques
Culicidae
Costs and Cost Analysis
Transgenes
Insertional Mutagenesis
Insects
Population

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Mosquito transgenesis : what is the fitness cost? / Marrelli, Mauro T.; Moreira, Cristina K.; Kelly, David; Alphey, Luke; Jacobs-Lorena, Marcelo.

In: Trends in Parasitology, Vol. 22, No. 5, 05.2006, p. 197-202.

Research output: Contribution to journalArticle

Marrelli, MT, Moreira, CK, Kelly, D, Alphey, L & Jacobs-Lorena, M 2006, 'Mosquito transgenesis: what is the fitness cost?', Trends in Parasitology, vol. 22, no. 5, pp. 197-202. https://doi.org/10.1016/j.pt.2006.03.004
Marrelli, Mauro T. ; Moreira, Cristina K. ; Kelly, David ; Alphey, Luke ; Jacobs-Lorena, Marcelo. / Mosquito transgenesis : what is the fitness cost?. In: Trends in Parasitology. 2006 ; Vol. 22, No. 5. pp. 197-202.
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