Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines

Mengdi Xu; Shengnan Lyu; Yingtian Xu; Can Kocabalkanli; Brian K. Chirikjian; John S. Chirikjian; Joshua Davis; Jin Seob Kim; Iulian Iordachita; Russell H. Taylor; Gregory S. Chirikjian

doi:10.1109/COASE.2019.8843147

Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines

Mengdi Xu, Shengnan Lyu, Yingtian Xu, Can Kocabalkanli, Brian K. Chirikjian, John S. Chirikjian, Joshua Davis, Jin Seob Kim, Iulian Iordachita, Russell H. Taylor, Gregory S. Chirikjian

Whiting School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

This paper describes the design of a fully automated apparatus to dispense mosquitoes into isolate units. This automation system consists of several process units including (1) facilitating the water vortex with a fan-shape rotor to gently transport the mosquitoes to the sorting slides with a conical geometry, (2) exploiting slides to guide mosquitoes to turntables driven by gears one by one, and (3) reorienting the mosquito until its proboscis points outward along the radial direction of the cone, aided by computer vision. This automation system serves as the first processing stage for collecting mosquito salivary glands. The sporozoites contained in the mosquito glands are the source material to produce Sanaria's first generation PfSPZ vaccines. The Mosquito Staging System can dramatically enhance the mass production of Malaria Vaccine which is essential to prevent the propagation of Malaria.

Original language	English (US)
Title of host publication	2019 IEEE 15th International Conference on Automation Science and Engineering, CASE 2019
Publisher	IEEE Computer Society
Pages	443-449
Number of pages	7
ISBN (Electronic)	9781728103556
DOIs	https://doi.org/10.1109/COASE.2019.8843147
State	Published - Aug 2019
Event	15th IEEE International Conference on Automation Science and Engineering, CASE 2019 - Vancouver, Canada Duration: Aug 22 2019 → Aug 26 2019

Publication series

Name	IEEE International Conference on Automation Science and Engineering
Volume	2019-August
ISSN (Print)	2161-8070
ISSN (Electronic)	2161-8089

Conference

Conference	15th IEEE International Conference on Automation Science and Engineering, CASE 2019
Country/Territory	Canada
City	Vancouver
Period	8/22/19 → 8/26/19

Keywords

Automation
Design
Malaria Vaccine
Medical Robot

ASJC Scopus subject areas

Control and Systems Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/COASE.2019.8843147

Cite this

Xu, M., Lyu, S., Xu, Y., Kocabalkanli, C., Chirikjian, B. K., Chirikjian, J. S., Davis, J., Kim, J. S., Iordachita, I., Taylor, R. H., & Chirikjian, G. S. (2019). Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines. In 2019 IEEE 15th International Conference on Automation Science and Engineering, CASE 2019 (pp. 443-449). Article 8843147 (IEEE International Conference on Automation Science and Engineering; Vol. 2019-August). IEEE Computer Society. https://doi.org/10.1109/COASE.2019.8843147

Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines. / Xu, Mengdi; Lyu, Shengnan; Xu, Yingtian et al.
2019 IEEE 15th International Conference on Automation Science and Engineering, CASE 2019. IEEE Computer Society, 2019. p. 443-449 8843147 (IEEE International Conference on Automation Science and Engineering; Vol. 2019-August).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Xu, M, Lyu, S, Xu, Y, Kocabalkanli, C, Chirikjian, BK, Chirikjian, JS, Davis, J, Kim, JS, Iordachita, I, Taylor, RH & Chirikjian, GS 2019, Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines. in 2019 IEEE 15th International Conference on Automation Science and Engineering, CASE 2019., 8843147, IEEE International Conference on Automation Science and Engineering, vol. 2019-August, IEEE Computer Society, pp. 443-449, 15th IEEE International Conference on Automation Science and Engineering, CASE 2019, Vancouver, Canada, 8/22/19. https://doi.org/10.1109/COASE.2019.8843147

Xu M, Lyu S, Xu Y, Kocabalkanli C, Chirikjian BK, Chirikjian JS et al. Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines. In 2019 IEEE 15th International Conference on Automation Science and Engineering, CASE 2019. IEEE Computer Society. 2019. p. 443-449. 8843147. (IEEE International Conference on Automation Science and Engineering). doi: 10.1109/COASE.2019.8843147

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title = "Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines",

abstract = "This paper describes the design of a fully automated apparatus to dispense mosquitoes into isolate units. This automation system consists of several process units including (1) facilitating the water vortex with a fan-shape rotor to gently transport the mosquitoes to the sorting slides with a conical geometry, (2) exploiting slides to guide mosquitoes to turntables driven by gears one by one, and (3) reorienting the mosquito until its proboscis points outward along the radial direction of the cone, aided by computer vision. This automation system serves as the first processing stage for collecting mosquito salivary glands. The sporozoites contained in the mosquito glands are the source material to produce Sanaria's first generation PfSPZ vaccines. The Mosquito Staging System can dramatically enhance the mass production of Malaria Vaccine which is essential to prevent the propagation of Malaria.",

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author = "Mengdi Xu and Shengnan Lyu and Yingtian Xu and Can Kocabalkanli and Chirikjian, {Brian K.} and Chirikjian, {John S.} and Joshua Davis and Kim, {Jin Seob} and Iulian Iordachita and Taylor, {Russell H.} and Chirikjian, {Gregory S.}",

note = "Funding Information: Thanks go to Ms. Jing Jia, Ms. Xia Wu, Mr. Bolin He and Mr. Mark Shifman for their discussions and help developing the preliminary apparatus. This work is supported in part by NIH SBIR grant 1R44AI134500-01 and in part by Johns Hopkins University internal funds. This work is with the collaboration of Sanaria, Inc. Rockville MD, USA. Publisher Copyright: {\textcopyright} 2019 IEEE.; 15th IEEE International Conference on Automation Science and Engineering, CASE 2019 ; Conference date: 22-08-2019 Through 26-08-2019",

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N1 - Funding Information: Thanks go to Ms. Jing Jia, Ms. Xia Wu, Mr. Bolin He and Mr. Mark Shifman for their discussions and help developing the preliminary apparatus. This work is supported in part by NIH SBIR grant 1R44AI134500-01 and in part by Johns Hopkins University internal funds. This work is with the collaboration of Sanaria, Inc. Rockville MD, USA. Publisher Copyright: © 2019 IEEE.

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N2 - This paper describes the design of a fully automated apparatus to dispense mosquitoes into isolate units. This automation system consists of several process units including (1) facilitating the water vortex with a fan-shape rotor to gently transport the mosquitoes to the sorting slides with a conical geometry, (2) exploiting slides to guide mosquitoes to turntables driven by gears one by one, and (3) reorienting the mosquito until its proboscis points outward along the radial direction of the cone, aided by computer vision. This automation system serves as the first processing stage for collecting mosquito salivary glands. The sporozoites contained in the mosquito glands are the source material to produce Sanaria's first generation PfSPZ vaccines. The Mosquito Staging System can dramatically enhance the mass production of Malaria Vaccine which is essential to prevent the propagation of Malaria.

AB - This paper describes the design of a fully automated apparatus to dispense mosquitoes into isolate units. This automation system consists of several process units including (1) facilitating the water vortex with a fan-shape rotor to gently transport the mosquitoes to the sorting slides with a conical geometry, (2) exploiting slides to guide mosquitoes to turntables driven by gears one by one, and (3) reorienting the mosquito until its proboscis points outward along the radial direction of the cone, aided by computer vision. This automation system serves as the first processing stage for collecting mosquito salivary glands. The sporozoites contained in the mosquito glands are the source material to produce Sanaria's first generation PfSPZ vaccines. The Mosquito Staging System can dramatically enhance the mass production of Malaria Vaccine which is essential to prevent the propagation of Malaria.

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Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this