Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines

Mengdi Xu, Shengnan Lyu, Yingtian Xu, Can Kocabalkanli, Brian K. Chirikjian, John S. Chirikjian, Joshua Davis, Jin Seob Kim, Iulian Iordachita, Russell H. Taylor, Gregory S. Chirikjian

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes the design of a fully automated apparatus to dispense mosquitoes into isolate units. This automation system consists of several process units including (1) facilitating the water vortex with a fan-shape rotor to gently transport the mosquitoes to the sorting slides with a conical geometry, (2) exploiting slides to guide mosquitoes to turntables driven by gears one by one, and (3) reorienting the mosquito until its proboscis points outward along the radial direction of the cone, aided by computer vision. This automation system serves as the first processing stage for collecting mosquito salivary glands. The sporozoites contained in the mosquito glands are the source material to produce Sanaria's first generation PfSPZ vaccines. The Mosquito Staging System can dramatically enhance the mass production of Malaria Vaccine which is essential to prevent the propagation of Malaria.

Original languageEnglish (US)
Title of host publication2019 IEEE 15th International Conference on Automation Science and Engineering, CASE 2019
PublisherIEEE Computer Society
Pages443-449
Number of pages7
ISBN (Electronic)9781728103556
DOIs
StatePublished - Aug 2019
Event15th IEEE International Conference on Automation Science and Engineering, CASE 2019 - Vancouver, Canada
Duration: Aug 22 2019Aug 26 2019

Publication series

NameIEEE International Conference on Automation Science and Engineering
Volume2019-August
ISSN (Print)2161-8070
ISSN (Electronic)2161-8089

Conference

Conference15th IEEE International Conference on Automation Science and Engineering, CASE 2019
CountryCanada
CityVancouver
Period8/22/198/26/19

Keywords

  • Automation
  • Design
  • Malaria Vaccine
  • Medical Robot

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Xu, M., Lyu, S., Xu, Y., Kocabalkanli, C., Chirikjian, B. K., Chirikjian, J. S., Davis, J., Kim, J. S., Iordachita, I., Taylor, R. H., & Chirikjian, G. S. (2019). Mosquito Staging Apparatus for Producing PfSPZ Malaria Vaccines. In 2019 IEEE 15th International Conference on Automation Science and Engineering, CASE 2019 (pp. 443-449). [8843147] (IEEE International Conference on Automation Science and Engineering; Vol. 2019-August). IEEE Computer Society. https://doi.org/10.1109/COASE.2019.8843147