@article{65aba48e0ec7493a8d0deef0a8a86209,
title = "Mosquito immune defenses against Plasmodium infection",
abstract = "The causative agent of malaria, Plasmodium, has to undergo complex developmental transitions and survive attacks from the mosquito's innate immune system to achieve transmission from one host to another through the vector. Here we discuss recent findings on the role of the mosquito's innate immune signaling pathways in preventing infection by the Plasmodium parasite, the identification and mechanistic description of novel anti-parasite molecules, the role that natural bacteria harbored in the mosquito midgut might play in this immune defense and the crucial parasite and vector molecules that mediate midgut infection.",
keywords = "Anopheles, Innate immunity, Malaria, Mosquito, Plasmodium",
author = "Cirimotich, {Chris M.} and Yuemei Dong and Garver, {Lindsey S.} and Shuzhen Sim and George Dimopoulos",
note = "Funding Information: We thank Dr. Deborah McClellan for editorial assistance. This work was supported by the Ellison Medical Foundation, the National Institutes of Health/National Institute for Allergy and Infectious Disease 1R01AI061576-01A1, RO1AI059492, RO1AI078997, the United Nations Development Program/World Bank/World Health Organization Special Program for Research and Training in Tropical Diseases, The National Science Foundation, and the Johns Hopkins School of Public Health. CC is supported by the Calvin and Helen Lang Scholarship. SS is supported by the Agency for Science, Technology and Research (A*STAR), Singapore. LG was supported by a National Science Foundation fellowship.",
year = "2010",
month = apr,
doi = "10.1016/j.dci.2009.12.005",
language = "English (US)",
volume = "34",
pages = "387--395",
journal = "Developmental and Comparative Immunology",
issn = "0145-305X",
publisher = "Elsevier Limited",
number = "4",
}