Mosquito gut antiparasitic and antiviral immunity

Raúl G. Saraiva, Seokyoung Kang, Maria L. Simões, Yesseinia I. Angleró-Rodríguez, George Dimopoulos

Research output: Contribution to journalArticle

Abstract

Mosquitoes are responsible for the transmission of diseases with a serious impact on global human health, such as malaria and dengue. All mosquito-transmitted pathogens complete part of their life cycle in the insect gut, where they are exposed to mosquito-encoded barriers and active factors that can limit their development. Here we present the current understanding of mosquito gut immunity against malaria parasites, filarial worms, and viruses such as dengue, Chikungunya, and West Nile. The most recently proposed immune mediators involved in intestinal defenses are discussed, as well as the synergies identified between the recognition of gut microbiota and the mounting of the immune response.

Original languageEnglish (US)
Pages (from-to)53-64
Number of pages12
JournalDevelopmental and Comparative Immunology
Volume64
DOIs
StatePublished - Nov 1 2016

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Keywords

  • Dengue
  • Innate immunity
  • Microbiota
  • Mosquito
  • Plasmodium

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

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