Mosquito antiviral immune pathways

Chinmay V. Tikhe, George Dimopoulos

Research output: Contribution to journalReview articlepeer-review

Abstract

Mosquitoes are vectors of a large number of viral pathogens. In recent years, increased urbanization and climate change has expanded the range of many vector mosquitoes. The lack of effective medical interventions has made the control of mosquito-borne viral diseases very difficult. Understanding the interactions between the mosquito immune system and viruses is critical if we are to develop effective control strategies against these diseases. Mosquitoes harbor multiple conserved immune pathways that curb invading viral pathogens. Despite the conservation of these pathways, the activation and intensity of the mosquito immune response varies with the mosquito species, tissue, and the infecting virus. This article reviews major conserved antiviral immune pathways in vector mosquitoes, their interactions with invading viral pathogens, and how these interactions restrict or promote infection of these medically important viruses.

Original languageEnglish (US)
Article number103964
JournalDevelopmental and Comparative Immunology
Volume116
DOIs
StatePublished - Mar 2021

Keywords

  • Antiviral
  • IMD
  • Immunity
  • JAK/STAT
  • Mosquito
  • RNAi
  • Toll

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

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