Mortality in mild cognitive impairment varies by subtype, sex, and lifestyle factors: The mayo clinic study of aging

Maria Vassilaki; Ruth H. Cha; Yonas E. Geda; Michelle M. Mielke; David S. Knopman; Ronald C. Petersen; Rosebud O. Roberts

doi:10.3233/JAD-143078

Mortality in mild cognitive impairment varies by subtype, sex, and lifestyle factors: The mayo clinic study of aging

Maria Vassilaki, Ruth H. Cha, Yonas E. Geda, Michelle M. Mielke, David S. Knopman, Ronald C. Petersen, Rosebud O. Roberts

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background: Etiologic differences in mild cognitive impairment (MCI) subtypes may impact mortality. Objective: To assess the rate of death in MCI overall, and by subtype, in the population-based Mayo Clinic Study of Aging. Methods: Participants aged 70-89 years at enrollment were clinically evaluated at baseline and 15-month intervals to assess diagnoses of MCI and dementia. Mortality in MCI cases versus cognitively normal (CN) individuals was estimated using Cox proportional hazards models. Results: Over a median follow-up of 5.8 years, 331 of 862 (38.4%) MCI cases and 224 of 1,292 (17.3%) cognitively normal participants died. Compared to CN individuals, mortality was elevated in persons with MCI (hazard ratio [HR] = 1.79; 95% CI: 1.41 to 2.27), and was higher for non-amnestic MCI (naMCI; HR = 2.40; 95% CI: 1.72 to 3.36) than for amnestic MCI (aMCI; HR = 1.61; 95% CI: 1.25 to 2.09) after adjusting for confounders. Mortality varied significantly by sex, education, history of heart disease, and engaging in moderate physical exercise (p for interaction

Original language	English (US)
Pages (from-to)	1237-1245
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	45
Issue number	4
DOIs	https://doi.org/10.3233/JAD-143078
State	Published - 2015
Externally published	Yes

Keywords

Cohort studies
incidence studies
mild cognitive impairment
mortality
outcomes research
prognosis

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Clinical Psychology

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title = "Mortality in mild cognitive impairment varies by subtype, sex, and lifestyle factors: The mayo clinic study of aging",

abstract = "Background: Etiologic differences in mild cognitive impairment (MCI) subtypes may impact mortality. Objective: To assess the rate of death in MCI overall, and by subtype, in the population-based Mayo Clinic Study of Aging. Methods: Participants aged 70-89 years at enrollment were clinically evaluated at baseline and 15-month intervals to assess diagnoses of MCI and dementia. Mortality in MCI cases versus cognitively normal (CN) individuals was estimated using Cox proportional hazards models. Results: Over a median follow-up of 5.8 years, 331 of 862 (38.4%) MCI cases and 224 of 1,292 (17.3%) cognitively normal participants died. Compared to CN individuals, mortality was elevated in persons with MCI (hazard ratio [HR] = 1.79; 95% CI: 1.41 to 2.27), and was higher for non-amnestic MCI (naMCI; HR = 2.40; 95% CI: 1.72 to 3.36) than for amnestic MCI (aMCI; HR = 1.61; 95% CI: 1.25 to 2.09) after adjusting for confounders. Mortality varied significantly by sex, education, history of heart disease, and engaging in moderate physical exercise (p for interaction ",

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AU - Mielke, Michelle M.

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AU - Petersen, Ronald C.

AU - Roberts, Rosebud O.

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AB - Background: Etiologic differences in mild cognitive impairment (MCI) subtypes may impact mortality. Objective: To assess the rate of death in MCI overall, and by subtype, in the population-based Mayo Clinic Study of Aging. Methods: Participants aged 70-89 years at enrollment were clinically evaluated at baseline and 15-month intervals to assess diagnoses of MCI and dementia. Mortality in MCI cases versus cognitively normal (CN) individuals was estimated using Cox proportional hazards models. Results: Over a median follow-up of 5.8 years, 331 of 862 (38.4%) MCI cases and 224 of 1,292 (17.3%) cognitively normal participants died. Compared to CN individuals, mortality was elevated in persons with MCI (hazard ratio [HR] = 1.79; 95% CI: 1.41 to 2.27), and was higher for non-amnestic MCI (naMCI; HR = 2.40; 95% CI: 1.72 to 3.36) than for amnestic MCI (aMCI; HR = 1.61; 95% CI: 1.25 to 2.09) after adjusting for confounders. Mortality varied significantly by sex, education, history of heart disease, and engaging in moderate physical exercise (p for interaction

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Mortality in mild cognitive impairment varies by subtype, sex, and lifestyle factors: The mayo clinic study of aging

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