Mortality after chronic hepatitis B virus infection: A linkage study involving 2 million parous women from Taiwan

Chyng Wen Fwu, Yin Chu Chien, Kenrad Edwin Nelson, Gregory D Kirk, San Lin You, Hsu Sung Kuo, Manning Feinleib, Chien Jen Chen

Research output: Contribution to journalArticle

Abstract

Background. Few studies have evaluated survival rates among women who have chronic hepatitis B virus infection. We investigated the overall and disease-specific mortality rates in a nationwide cohort of women after they were screened for hepatitis B surface antigen (HBsAg) during pregnancy. Methods. HBsAg prenatal screening data were available for 2,087,994 women in Taiwan between 1 January 1986 and 31 March 2000 in the National Hepatitis B Vaccination Registry. Their vital status and cause of death were ascertained by computerized linkage with the National Death Certification Registry. Cox proportional hazards models were used to estimate the association between HBsAg status and specific causes of death. Results. Overall, 14,524 deaths were identified after a mean of 11.43 years of follow-up. The age-adjusted hazard ratio for mortality among HBsAg carriers compared with noncarriers was 1.24 (95% confidence interval [CI], 1.19-1.30), 6.59 (95% CI, 5.70-7.61), and 1.09 (95% CI, 1.04-1.14) for all-cause, liver-specific, and nonliver-related deaths, respectively. In addition to liver-specific causes, a significantly increased risk of mortality from non-Hodgkin lymphoma (P

Original languageEnglish (US)
Pages (from-to)1016-1023
Number of pages8
JournalJournal of Infectious Diseases
Volume201
Issue number7
DOIs
StatePublished - Apr 1 2010

Fingerprint

Chronic Hepatitis B
Virus Diseases
Hepatitis B Surface Antigens
Taiwan
Hepatitis B virus
Mortality
Confidence Intervals
Registries
Cause of Death
Liver
Certification
Hepatitis B
Prenatal Diagnosis
Proportional Hazards Models
Non-Hodgkin's Lymphoma
Vaccination
Survival Rate
Pregnancy

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Mortality after chronic hepatitis B virus infection : A linkage study involving 2 million parous women from Taiwan. / Fwu, Chyng Wen; Chien, Yin Chu; Nelson, Kenrad Edwin; Kirk, Gregory D; You, San Lin; Kuo, Hsu Sung; Feinleib, Manning; Chen, Chien Jen.

In: Journal of Infectious Diseases, Vol. 201, No. 7, 01.04.2010, p. 1016-1023.

Research output: Contribution to journalArticle

Fwu, Chyng Wen ; Chien, Yin Chu ; Nelson, Kenrad Edwin ; Kirk, Gregory D ; You, San Lin ; Kuo, Hsu Sung ; Feinleib, Manning ; Chen, Chien Jen. / Mortality after chronic hepatitis B virus infection : A linkage study involving 2 million parous women from Taiwan. In: Journal of Infectious Diseases. 2010 ; Vol. 201, No. 7. pp. 1016-1023.
@article{25dec9cad0944154931db64adaf708df,
title = "Mortality after chronic hepatitis B virus infection: A linkage study involving 2 million parous women from Taiwan",
abstract = "Background. Few studies have evaluated survival rates among women who have chronic hepatitis B virus infection. We investigated the overall and disease-specific mortality rates in a nationwide cohort of women after they were screened for hepatitis B surface antigen (HBsAg) during pregnancy. Methods. HBsAg prenatal screening data were available for 2,087,994 women in Taiwan between 1 January 1986 and 31 March 2000 in the National Hepatitis B Vaccination Registry. Their vital status and cause of death were ascertained by computerized linkage with the National Death Certification Registry. Cox proportional hazards models were used to estimate the association between HBsAg status and specific causes of death. Results. Overall, 14,524 deaths were identified after a mean of 11.43 years of follow-up. The age-adjusted hazard ratio for mortality among HBsAg carriers compared with noncarriers was 1.24 (95{\%} confidence interval [CI], 1.19-1.30), 6.59 (95{\%} CI, 5.70-7.61), and 1.09 (95{\%} CI, 1.04-1.14) for all-cause, liver-specific, and nonliver-related deaths, respectively. In addition to liver-specific causes, a significantly increased risk of mortality from non-Hodgkin lymphoma (P",
author = "Fwu, {Chyng Wen} and Chien, {Yin Chu} and Nelson, {Kenrad Edwin} and Kirk, {Gregory D} and You, {San Lin} and Kuo, {Hsu Sung} and Manning Feinleib and Chen, {Chien Jen}",
year = "2010",
month = "4",
day = "1",
doi = "10.1086/651231",
language = "English (US)",
volume = "201",
pages = "1016--1023",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Mortality after chronic hepatitis B virus infection

T2 - A linkage study involving 2 million parous women from Taiwan

AU - Fwu, Chyng Wen

AU - Chien, Yin Chu

AU - Nelson, Kenrad Edwin

AU - Kirk, Gregory D

AU - You, San Lin

AU - Kuo, Hsu Sung

AU - Feinleib, Manning

AU - Chen, Chien Jen

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Background. Few studies have evaluated survival rates among women who have chronic hepatitis B virus infection. We investigated the overall and disease-specific mortality rates in a nationwide cohort of women after they were screened for hepatitis B surface antigen (HBsAg) during pregnancy. Methods. HBsAg prenatal screening data were available for 2,087,994 women in Taiwan between 1 January 1986 and 31 March 2000 in the National Hepatitis B Vaccination Registry. Their vital status and cause of death were ascertained by computerized linkage with the National Death Certification Registry. Cox proportional hazards models were used to estimate the association between HBsAg status and specific causes of death. Results. Overall, 14,524 deaths were identified after a mean of 11.43 years of follow-up. The age-adjusted hazard ratio for mortality among HBsAg carriers compared with noncarriers was 1.24 (95% confidence interval [CI], 1.19-1.30), 6.59 (95% CI, 5.70-7.61), and 1.09 (95% CI, 1.04-1.14) for all-cause, liver-specific, and nonliver-related deaths, respectively. In addition to liver-specific causes, a significantly increased risk of mortality from non-Hodgkin lymphoma (P

AB - Background. Few studies have evaluated survival rates among women who have chronic hepatitis B virus infection. We investigated the overall and disease-specific mortality rates in a nationwide cohort of women after they were screened for hepatitis B surface antigen (HBsAg) during pregnancy. Methods. HBsAg prenatal screening data were available for 2,087,994 women in Taiwan between 1 January 1986 and 31 March 2000 in the National Hepatitis B Vaccination Registry. Their vital status and cause of death were ascertained by computerized linkage with the National Death Certification Registry. Cox proportional hazards models were used to estimate the association between HBsAg status and specific causes of death. Results. Overall, 14,524 deaths were identified after a mean of 11.43 years of follow-up. The age-adjusted hazard ratio for mortality among HBsAg carriers compared with noncarriers was 1.24 (95% confidence interval [CI], 1.19-1.30), 6.59 (95% CI, 5.70-7.61), and 1.09 (95% CI, 1.04-1.14) for all-cause, liver-specific, and nonliver-related deaths, respectively. In addition to liver-specific causes, a significantly increased risk of mortality from non-Hodgkin lymphoma (P

UR - http://www.scopus.com/inward/record.url?scp=77749306165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77749306165&partnerID=8YFLogxK

U2 - 10.1086/651231

DO - 10.1086/651231

M3 - Article

C2 - 20187745

AN - SCOPUS:77749306165

VL - 201

SP - 1016

EP - 1023

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 7

ER -