Morphometry of the amygdala in schizophrenia and psychotic bipolar disorder

Pamela B. Mahon, David S. Lee, Huong Trinh, Daniel Tward, Michael I. Miller, Laurent Younes, Patrick E. Barta, J. Tilak Ratnanather

Research output: Contribution to journalArticlepeer-review


Volumetric studies suggest smaller amygdalae in subjects with schizophrenia (SZ) than with bipolar disorder (BP). We use morphometry to identify subregions of amygdala differentially affected in SZ and psychotic BP. Based on template centered population analysis, the shape of the amygdala in psychotic BP differs from SZ (pleft=0.044, pright=0.042). Using a high-field 7T atlas, the bilateral basolateral, basomedial and centromedial subregions and the right lateral subregion were significantly atrophied in SZ compared to psychotic BP (p<0.02). These results suggest that change in shape of amygdala may represent a morphologic feature distinguishing SZ from psychotic BP.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalSchizophrenia Research
Issue number1-3
StatePublished - May 1 2015


  • Amygdala
  • Morphometry
  • Psychotic bipolar disorder
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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