Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder

J. Tilak Ratnanather, Clare B. Poynton, Dominic V. Pisano, Britni Crocker, Elizabeth Postell, Shannon Cebron, Elvan Ceyhan, Nancy A. Honeycutt, Pamela B. Mahon, Patrick Ernest Barta

Research output: Contribution to journalArticle

Abstract

Structural abnormalities in temporal lobe, including the superior temporal gyrus (STG) and planum temporale (PT), have been reported in schizophrenia (SCZ) and bipolar disorder (BPD) patients. While most MRI studies have suggested gray matter volume and surface area reduction in temporal lobe regions, few have explored changes in laminar thickness in PT and STG in SCZ and BPD. ROI subvolumes of the STG from 94 subjects were used to yield gray matter volume, gray/white surface area and laminar thickness for STG and PT cortical regions. Morphometric analysis suggests that there may be gender and laterality effects on the size and shape of the PT in BPD (n= 36) and SCZ (n= 31) with reduced laterality in PT in subjects with SCZ but not in BPD. In addition, PT surface area was seen to be larger in males, and asymmetry in PT surface area was larger in BPD. Subjects with SCZ had reduced thickness and smaller asymmetry in PT volume. Thus, the PT probably plays a more sensitive role than the STG in structural abnormalities seen in SCZ.

Original languageEnglish (US)
Pages (from-to)476-483
Number of pages8
JournalSchizophrenia Research
Volume150
Issue number2-3
DOIs
StatePublished - Nov 2013

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Temazepam
Temporal Lobe
Bipolar Disorder
Psychotic Disorders
Schizophrenia

Keywords

  • Bipolar disorder
  • Laminar thickness
  • Laterality
  • Planum temporale
  • Schizophrenia
  • Superior temporal gyrus

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder. / Ratnanather, J. Tilak; Poynton, Clare B.; Pisano, Dominic V.; Crocker, Britni; Postell, Elizabeth; Cebron, Shannon; Ceyhan, Elvan; Honeycutt, Nancy A.; Mahon, Pamela B.; Barta, Patrick Ernest.

In: Schizophrenia Research, Vol. 150, No. 2-3, 11.2013, p. 476-483.

Research output: Contribution to journalArticle

Ratnanather, JT, Poynton, CB, Pisano, DV, Crocker, B, Postell, E, Cebron, S, Ceyhan, E, Honeycutt, NA, Mahon, PB & Barta, PE 2013, 'Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder', Schizophrenia Research, vol. 150, no. 2-3, pp. 476-483. https://doi.org/10.1016/j.schres.2013.08.014
Ratnanather, J. Tilak ; Poynton, Clare B. ; Pisano, Dominic V. ; Crocker, Britni ; Postell, Elizabeth ; Cebron, Shannon ; Ceyhan, Elvan ; Honeycutt, Nancy A. ; Mahon, Pamela B. ; Barta, Patrick Ernest. / Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder. In: Schizophrenia Research. 2013 ; Vol. 150, No. 2-3. pp. 476-483.
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