TY - JOUR
T1 - Morphometry of isolated tumor cells in breast cancer sentinel lymph nodes
T2 - Metastases or displacement?
AU - Van Deurzen, Carolien H M
AU - Bult, Peter
AU - De Boer, Maaike
AU - Koelemij, Ron
AU - Van Hillegersberg, Richard
AU - Tjan-Heijnen, Vivianne C G
AU - Hobbelink, Monique G G
AU - De Bruin, Peter C.
AU - Van Diest, Paul J.
PY - 2009/1
Y1 - 2009/1
N2 - Iatrogenic displacement and mechanical transport of epithelial cells to the sentinel node (SN) has been suggested to result in false-positive findings in breast cancer patients, but little biologic evidence has yet been presented for this hypothesis. As malignant nuclei are larger than benign ones, nuclear morphometry of SN isolated tumor cells (ITC) could provide relevant information with regard to the malignant origin-or-not of epithelial cells in the SN. In patients with primary invasive breast cancer and SN ITC with (N=16) or without (N=45) non-SN involvement, nuclear morphometry was performed on the primary tumor as well as on the ITC in the SN. Nuclear size in the primary tumor was compared with that in the corresponding ITC. Patients with SN micrometastases (N=30) and SN macrometastases (N=30) served as controls. Nuclear size of ITC was significantly smaller compared with nuclear size of the corresponding primary tumor (P
AB - Iatrogenic displacement and mechanical transport of epithelial cells to the sentinel node (SN) has been suggested to result in false-positive findings in breast cancer patients, but little biologic evidence has yet been presented for this hypothesis. As malignant nuclei are larger than benign ones, nuclear morphometry of SN isolated tumor cells (ITC) could provide relevant information with regard to the malignant origin-or-not of epithelial cells in the SN. In patients with primary invasive breast cancer and SN ITC with (N=16) or without (N=45) non-SN involvement, nuclear morphometry was performed on the primary tumor as well as on the ITC in the SN. Nuclear size in the primary tumor was compared with that in the corresponding ITC. Patients with SN micrometastases (N=30) and SN macrometastases (N=30) served as controls. Nuclear size of ITC was significantly smaller compared with nuclear size of the corresponding primary tumor (P
KW - Breast cancer
KW - Isolated tumor cells
KW - Morphometry
KW - Sentinel node
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U2 - 10.1097/PAS.0b013e31817eec40
DO - 10.1097/PAS.0b013e31817eec40
M3 - Article
C2 - 18852675
AN - SCOPUS:59149094655
SN - 0147-5185
VL - 33
SP - 106
EP - 110
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 1
ER -