Morphometry of isolated tumor cells in breast cancer sentinel lymph nodes: Metastases or displacement?

Carolien H M Van Deurzen, Peter Bult, Maaike De Boer, Ron Koelemij, Richard Van Hillegersberg, Vivianne C G Tjan-Heijnen, Monique G G Hobbelink, Peter C. De Bruin, Paul J. Van Diest

Research output: Contribution to journalArticle

Abstract

Iatrogenic displacement and mechanical transport of epithelial cells to the sentinel node (SN) has been suggested to result in false-positive findings in breast cancer patients, but little biologic evidence has yet been presented for this hypothesis. As malignant nuclei are larger than benign ones, nuclear morphometry of SN isolated tumor cells (ITC) could provide relevant information with regard to the malignant origin-or-not of epithelial cells in the SN. In patients with primary invasive breast cancer and SN ITC with (N=16) or without (N=45) non-SN involvement, nuclear morphometry was performed on the primary tumor as well as on the ITC in the SN. Nuclear size in the primary tumor was compared with that in the corresponding ITC. Patients with SN micrometastases (N=30) and SN macrometastases (N=30) served as controls. Nuclear size of ITC was significantly smaller compared with nuclear size of the corresponding primary tumor (P

Original languageEnglish (US)
Pages (from-to)106-110
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume33
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

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Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Epithelial Cells
Neoplasm Micrometastasis
Sentinel Lymph Node
cyhalothrin

Keywords

  • Breast cancer
  • Isolated tumor cells
  • Morphometry
  • Sentinel node

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

Cite this

Van Deurzen, C. H. M., Bult, P., De Boer, M., Koelemij, R., Van Hillegersberg, R., Tjan-Heijnen, V. C. G., ... Van Diest, P. J. (2009). Morphometry of isolated tumor cells in breast cancer sentinel lymph nodes: Metastases or displacement? American Journal of Surgical Pathology, 33(1), 106-110. https://doi.org/10.1097/PAS.0b013e31817eec40

Morphometry of isolated tumor cells in breast cancer sentinel lymph nodes : Metastases or displacement? / Van Deurzen, Carolien H M; Bult, Peter; De Boer, Maaike; Koelemij, Ron; Van Hillegersberg, Richard; Tjan-Heijnen, Vivianne C G; Hobbelink, Monique G G; De Bruin, Peter C.; Van Diest, Paul J.

In: American Journal of Surgical Pathology, Vol. 33, No. 1, 01.2009, p. 106-110.

Research output: Contribution to journalArticle

Van Deurzen, CHM, Bult, P, De Boer, M, Koelemij, R, Van Hillegersberg, R, Tjan-Heijnen, VCG, Hobbelink, MGG, De Bruin, PC & Van Diest, PJ 2009, 'Morphometry of isolated tumor cells in breast cancer sentinel lymph nodes: Metastases or displacement?', American Journal of Surgical Pathology, vol. 33, no. 1, pp. 106-110. https://doi.org/10.1097/PAS.0b013e31817eec40
Van Deurzen, Carolien H M ; Bult, Peter ; De Boer, Maaike ; Koelemij, Ron ; Van Hillegersberg, Richard ; Tjan-Heijnen, Vivianne C G ; Hobbelink, Monique G G ; De Bruin, Peter C. ; Van Diest, Paul J. / Morphometry of isolated tumor cells in breast cancer sentinel lymph nodes : Metastases or displacement?. In: American Journal of Surgical Pathology. 2009 ; Vol. 33, No. 1. pp. 106-110.
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