Morphometric study of myocardial changes during puromycin aminonucleoside induced nephropathy in rats

W. J F Van Der Vijgh; D. Van Velzen; J. S E M Van Der Poort; H. M M Schluper; K. Mross; J. Feijen; H. M. Pinedo

Morphometric study of myocardial changes during puromycin aminonucleoside induced nephropathy in rats

W. J F Van Der Vijgh, D. Van Velzen, J. S E M Van Der Poort, H. M M Schluper, K. Mross, J. Feijen, H. M. Pinedo

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Abstract

Puromycin aminonucleoside (PAN)-treated rats developed a severe nephrotic syndrome. Morphometric analysis of the hearts revealed significant differences between treated and control rats regarding nuclear index, reticulin index, nuclear and myocellular transsectional area, capillary number and transsectional area of capillaries. These differences were comparable with those induced by adriamycin. It is suggested that PAN can induce morphometrically measurable abnormalities in hearts of rats comparable to the morphometric changes seen after adriamycin treatment. The question of whether nephropathy, a result of both DOX and PAN treatment of rats, adds to or perhaps even causes doxorubicin - induced cardiomyopathy remains unclear.

Original language	English (US)
Pages (from-to)	1111-1116
Number of pages	6
Journal	Anticancer Research
Volume	7
Issue number	6
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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title = "Morphometric study of myocardial changes during puromycin aminonucleoside induced nephropathy in rats",

abstract = "Puromycin aminonucleoside (PAN)-treated rats developed a severe nephrotic syndrome. Morphometric analysis of the hearts revealed significant differences between treated and control rats regarding nuclear index, reticulin index, nuclear and myocellular transsectional area, capillary number and transsectional area of capillaries. These differences were comparable with those induced by adriamycin. It is suggested that PAN can induce morphometrically measurable abnormalities in hearts of rats comparable to the morphometric changes seen after adriamycin treatment. The question of whether nephropathy, a result of both DOX and PAN treatment of rats, adds to or perhaps even causes doxorubicin - induced cardiomyopathy remains unclear.",

author = "{Van Der Vijgh}, {W. J F} and {Van Velzen}, D. and {Van Der Poort}, {J. S E M} and Schluper, {H. M M} and K. Mross and J. Feijen and Pinedo, {H. M.}",

year = "1987",

language = "English (US)",

volume = "7",

pages = "1111--1116",

journal = "Anticancer Research",

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T1 - Morphometric study of myocardial changes during puromycin aminonucleoside induced nephropathy in rats

AU - Van Der Vijgh, W. J F

AU - Van Velzen, D.

AU - Van Der Poort, J. S E M

AU - Schluper, H. M M

AU - Mross, K.

AU - Feijen, J.

AU - Pinedo, H. M.

PY - 1987

Y1 - 1987

N2 - Puromycin aminonucleoside (PAN)-treated rats developed a severe nephrotic syndrome. Morphometric analysis of the hearts revealed significant differences between treated and control rats regarding nuclear index, reticulin index, nuclear and myocellular transsectional area, capillary number and transsectional area of capillaries. These differences were comparable with those induced by adriamycin. It is suggested that PAN can induce morphometrically measurable abnormalities in hearts of rats comparable to the morphometric changes seen after adriamycin treatment. The question of whether nephropathy, a result of both DOX and PAN treatment of rats, adds to or perhaps even causes doxorubicin - induced cardiomyopathy remains unclear.

AB - Puromycin aminonucleoside (PAN)-treated rats developed a severe nephrotic syndrome. Morphometric analysis of the hearts revealed significant differences between treated and control rats regarding nuclear index, reticulin index, nuclear and myocellular transsectional area, capillary number and transsectional area of capillaries. These differences were comparable with those induced by adriamycin. It is suggested that PAN can induce morphometrically measurable abnormalities in hearts of rats comparable to the morphometric changes seen after adriamycin treatment. The question of whether nephropathy, a result of both DOX and PAN treatment of rats, adds to or perhaps even causes doxorubicin - induced cardiomyopathy remains unclear.

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Morphometric study of myocardial changes during puromycin aminonucleoside induced nephropathy in rats

Abstract

ASJC Scopus subject areas

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