Morphometric and qualitative analysis of congenital occipitocervical instability in children: Implications for patients with Down syndrome

Samuel Browd, Lindsay J. Healy, Ginger Dobie, J. Thomas Johnson, Greg M. Jones, Luis F. Rodriguez, Douglas L. Brockmeyer

Research output: Contribution to journalArticlepeer-review

Abstract

Object. Congenital occipitocervical (OC) instability is uncommon in healthy children but can occur in many children with Down syndrome. A simple morphometric method of evaluating the OC joint in children with OC instability is presented, supported by a qualitative image analysis based on computed tomography (CT). Methods. Thin-cut CT scans of the OC joint were obtained in eight patients with Down syndrome and one patient with congenital OC instability. These patients' CT scans were compared with those of 15 healthy age-matched control individuals. Morphometric analysis was performed by measuring the depth and length of the superior articular surface (SAS) of C-1, and these values were normalized for a comparison between groups. Qualitative data were acquired using a surface-rendering technique for a visual comparison of the C-1 SAS. Morphometric analysis demonstrated an absence of the concave C-1 SAS anatomy in patients with congenital OC instability compared with age-matched control individuals (0.083 compared with 0.202, p < 0.001). Three-dimensional (3D) image analysis of the C-1 SAS supported this finding. Conclusions. Congenital differences in the shape of the OC joint are highly associated with atraumatic OC instability in children with Down syndrome. High-resolution CT imaging combined with 3D rendering techniques and surface mapping provides support for this assessment. It appears that abnormal OC joint shape is a contributing factor to congenital OC instability, especially in patients with Down syndrome.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalJournal of neurosurgery
Volume105 PEDIATRICS
Issue numberSUPPL. 1
DOIs
StatePublished - Jul 2006
Externally publishedYes

Keywords

  • Down syndrome
  • Occipitocervical instability
  • Occipitocervical morphology
  • Pediatric neurosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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