Abstract
The peripheral blood lymphocytes of a patient with clinically diagnosed chronic lymphocytic leukemia were studied morphologically and functionally. They appeared to be classical small lymphocytes with no features of Sezary cells. Only 1% of the cells stained positively with fluorescent anti Ig sera or with aggregated Ig, and 5% formed rosettes with sheep erythrocytes coated with antibody and human complement (EAC). On the other hand, 95% of the lymphocytes formed spontaneous rosettes with sheep erythrocytes, and 95% or greater were killed by antiserum raised to T lymphocytes. The proliferative responses also indicated that these cells reacted as T cells. It is interesting that while the cells from this patient stimulated very well in a mixed lymphocyte reaction, they were not stimulated by the lymphocytes of three individuals. Our results indicate that this is a T cell leukemia, and the results of the MLR seem to point that the cell proliferates as a clone.
Original language | English (US) |
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Pages (from-to) | 382-391 |
Number of pages | 10 |
Journal | Clinical Immunology and Immunopathology |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology