Morphologic observations on experimental vascularization in the rat

J. S. McCracken, P. C. Burger, G. K. Klintworth

Research output: Contribution to journalArticle

Abstract

The morphologic evolution of the early events of corneal vascularization in the rat cornea induced by silver nitrate cautery were followed by light and electron microscopy. An initial acute inflammatory response occurred within the first 6 hours after cautery as evidenced by vascular dilation, diapedesis of leukocytes, and an increased vascular permeability, as manifested by distended lymphatics and the presence of extravascular fibrin. At 24 hours after injury, the hypertrophy and the prominence of nucleoli and the presence of abundant polyribosomes were the initial suggestion that vascular endothelial cells and pericytes had entered the mitotic cycle. Nine hours later, at 33 hours after cautery, the first new vessels were observed as sprouts from the capillary arcade and postcapillary venules. The experiments reemphasize the association of acute inflammation and corneal vascularization in this model and underscore the early occurrence of vascular endothelial cell replication.

Original languageEnglish (US)
Pages (from-to)519-530
Number of pages12
JournalLaboratory Investigation
Volume41
Issue number6
StatePublished - 1979
Externally publishedYes

Fingerprint

Cautery
Endothelial Cells
Transendothelial and Transepithelial Migration
Silver Nitrate
Pericytes
Polyribosomes
Venules
Capillary Permeability
Fibrin
Cornea
Hypertrophy
Blood Vessels
Dilatation
Electron Microscopy
Leukocytes
Inflammation
Light
Wounds and Injuries

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

McCracken, J. S., Burger, P. C., & Klintworth, G. K. (1979). Morphologic observations on experimental vascularization in the rat. Laboratory Investigation, 41(6), 519-530.

Morphologic observations on experimental vascularization in the rat. / McCracken, J. S.; Burger, P. C.; Klintworth, G. K.

In: Laboratory Investigation, Vol. 41, No. 6, 1979, p. 519-530.

Research output: Contribution to journalArticle

McCracken, JS, Burger, PC & Klintworth, GK 1979, 'Morphologic observations on experimental vascularization in the rat', Laboratory Investigation, vol. 41, no. 6, pp. 519-530.
McCracken JS, Burger PC, Klintworth GK. Morphologic observations on experimental vascularization in the rat. Laboratory Investigation. 1979;41(6):519-530.
McCracken, J. S. ; Burger, P. C. ; Klintworth, G. K. / Morphologic observations on experimental vascularization in the rat. In: Laboratory Investigation. 1979 ; Vol. 41, No. 6. pp. 519-530.
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