Morphologic observations of brain tumors in PD4 hamsters induced by four strains of Avian Sarcoma Virus

Peter C. Burger, Darell D. Bigner, Donnie J. Self

Research output: Contribution to journalArticle

Abstract

Brain tumors were induced in inbred PD4 hamsters with each of four strains of Avian Sarcoma Virus: CT-559, Bratislava-77, Schmidt-Ruppin, and Bryan. Based on light and electron microscopic observations the neoplastic tissues found in these tumors were identified as: (1) glial, (2) a distinctive large cell, and (3) sarcomatous. The glial neoplasms consisted almost entirely of masses of astrocytes in a subependymal position. The large cell tissue was a striking feature in some of the tumors. Although the cell of origin for this tissue could not be positively identified, certain features suggested that these cells were derived from glia. The cerebral sarcomas occurred as small nodules near the pial surface or occasionally as large intracerebral masses. Replicating virus was not seen in any of the tumors.

Original languageEnglish (US)
Pages (from-to)1-21
Number of pages21
JournalActa neuropathologica
Volume26
Issue number1
DOIs
StatePublished - Mar 1 1973

Keywords

  • Astrocytoma
  • Avian Sarcoma Virus
  • Experimental Brain Tumor
  • Glioma
  • Nexus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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