Morphologic alterations in HIV-infected people with lipodystrophy are associated with good adherence to HAART

Giovanni Guaraldi, Rita Murri, Gabriella Orlando, Emanuele Orlandi, Gaetana Sterrantino, Marco Borderi, Carmela Grosso, Anna Maria Cattelan, Giulia Nardini, Barbara Beghetto, Andrea Antinori, Roberto Esposito, Albert W. Wu

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the association between adherence to drugs and morphologic alterations (MOA) in a cohort of HIV-infected patients on HAART. Method: This was a cross-sectional multicenter cohort study in eight tertiary Clinical Centers of Northern and Central Italy. Consecutive outpatients taking HAART were enrolled from August 2000 to March 2001. They completed a self-administered questionnaire for the evaluation of signs of MOA and the self-reported adherence to drugs. Main outcome measures were MOA according to the Multicenter AIDS Cohort Study (MACS) definition and adherence to drugs. Results: One hundred seventy-five persons were enrolled into the study. Median CD4 cell count was 522 (interquartile range [IQR] 306-720); 35% of people had undetectable HIV RNA. Patients had been taking HAART for a median of 53 months (IQR 33-62). Among enrolled patients, 83 (47%) had a diagnosis of self-reported MOA; 57 of them reported body changes of more than 12 months duration. Forty persons (23%) self-reported nonadherence in the previous week. Mean time on HAART was 48.7 months (SD = 19.7) for people with MOA and 42.1 months (SD = 21.8) for those without MOA (p =.043). The odds of adherence for people with MOA was 2.36 times (95% CI 1.11-5.00) higher than for people without MOA. On multivariate analysis, being older and female, having an undetectable HIV RNA, longer duration on HAART, and self-reported adherence were independently associated with the presence of MOA. In people with MOA, adherence seems to decrease over time. Conclusion: Longer time on HAART and self-reported adherence were correlated to MOA. MOA was also associated with older age and female gender.

Original languageEnglish (US)
Pages (from-to)99-106
Number of pages8
JournalHIV Clinical Trials
Volume4
Issue number2
DOIs
StatePublished - Mar 1 2003

Keywords

  • Adherence
  • HAART
  • Morphologic alterations

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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    Guaraldi, G., Murri, R., Orlando, G., Orlandi, E., Sterrantino, G., Borderi, M., Grosso, C., Cattelan, A. M., Nardini, G., Beghetto, B., Antinori, A., Esposito, R., & Wu, A. W. (2003). Morphologic alterations in HIV-infected people with lipodystrophy are associated with good adherence to HAART. HIV Clinical Trials, 4(2), 99-106. https://doi.org/10.1310/W1QF-C9X9-9PFT-88JK