TY - JOUR
T1 - Morphine pharmacokinetics during anesthesia and surgery in patients with burns
AU - Furman, William R.
AU - Munster, Andrew M.
AU - Cone, Edward J.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - The plasma clearance, plasma half-life, and apparent volume of distribution of morphine during anesthesia and surgery were determined in seven patients with burns and compared with seven age-matched control subjects. The burn group had a significantly lower clearance, longer terminal half-life, and smaller volume of distribution than the control group. The clearance was 12 ± 2 ml/min/kg, the half-life was 123 ± 24 minutes, and the volume of distribution was 2.2 ± 0.4 L/kg for the subjects with burns compared with 25 ± 3 ml/min/kg, 89 ± 18 minutes, and 3.2 ± 0.8 L/kg for the control subjects (P < 0.001, <0.02, and <0.02, respectively). These data contrast with the theory that patients with burns have a tolerance to narcotics and suggest the need for further study of the pharmacologic effects of burn injury and surgery.
AB - The plasma clearance, plasma half-life, and apparent volume of distribution of morphine during anesthesia and surgery were determined in seven patients with burns and compared with seven age-matched control subjects. The burn group had a significantly lower clearance, longer terminal half-life, and smaller volume of distribution than the control group. The clearance was 12 ± 2 ml/min/kg, the half-life was 123 ± 24 minutes, and the volume of distribution was 2.2 ± 0.4 L/kg for the subjects with burns compared with 25 ± 3 ml/min/kg, 89 ± 18 minutes, and 3.2 ± 0.8 L/kg for the control subjects (P < 0.001, <0.02, and <0.02, respectively). These data contrast with the theory that patients with burns have a tolerance to narcotics and suggest the need for further study of the pharmacologic effects of burn injury and surgery.
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U2 - 10.1097/00004630-199009000-00003
DO - 10.1097/00004630-199009000-00003
M3 - Article
C2 - 2246307
AN - SCOPUS:0025064806
VL - 11
SP - 391
EP - 394
JO - Journal of Burn Care and Research
JF - Journal of Burn Care and Research
SN - 1559-047X
IS - 5
ER -