Morphine catalepsy in the rat: Involvement of μ1 (high affinity) opioid binding sites

Geoffrey S.F. Ling, Gavril W. Pasternak

Research output: Contribution to journalArticlepeer-review

Abstract

Since the proposal of multiple classes of opiate receptors, much effort has been devoted to understanding the subtypes mediating specific opioid actions. Using the irreversible antagonist naloxozone, we have established a role for the high affinity (μ1) sites in analgesia. These sites also appear important in opiate catalepsy. Control rats showed dramatic catalepsy following a high dose of morphine sulfate (100 mg/kg, s.c.). Rats whose high affinity (μ1) sites had been blocked with naloxazone 24 h earlier, on the other hand, showed no evidence of catalepsy (P < 0.01). Accordingly, catalepsy appears to involve the same receptors as analgesia, the higher affinity (μ1) sites.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalNeuroscience Letters
Volume32
Issue number2
DOIs
StatePublished - Oct 8 1982

ASJC Scopus subject areas

  • Neuroscience(all)

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