TY - JOUR
T1 - Morphine catalepsy in the rat
T2 - Involvement of μ1 (high affinity) opioid binding sites
AU - Ling, Geoffrey S.F.
AU - Pasternak, Gavril W.
PY - 1982/10/8
Y1 - 1982/10/8
N2 - Since the proposal of multiple classes of opiate receptors, much effort has been devoted to understanding the subtypes mediating specific opioid actions. Using the irreversible antagonist naloxozone, we have established a role for the high affinity (μ1) sites in analgesia. These sites also appear important in opiate catalepsy. Control rats showed dramatic catalepsy following a high dose of morphine sulfate (100 mg/kg, s.c.). Rats whose high affinity (μ1) sites had been blocked with naloxazone 24 h earlier, on the other hand, showed no evidence of catalepsy (P < 0.01). Accordingly, catalepsy appears to involve the same receptors as analgesia, the higher affinity (μ1) sites.
AB - Since the proposal of multiple classes of opiate receptors, much effort has been devoted to understanding the subtypes mediating specific opioid actions. Using the irreversible antagonist naloxozone, we have established a role for the high affinity (μ1) sites in analgesia. These sites also appear important in opiate catalepsy. Control rats showed dramatic catalepsy following a high dose of morphine sulfate (100 mg/kg, s.c.). Rats whose high affinity (μ1) sites had been blocked with naloxazone 24 h earlier, on the other hand, showed no evidence of catalepsy (P < 0.01). Accordingly, catalepsy appears to involve the same receptors as analgesia, the higher affinity (μ1) sites.
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U2 - 10.1016/0304-3940(82)90273-7
DO - 10.1016/0304-3940(82)90273-7
M3 - Article
C2 - 6292799
AN - SCOPUS:0020477721
SN - 0304-3940
VL - 32
SP - 193
EP - 196
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -