Morphine alters preproenkephalin gene expression

George R. Uhl; James P. Ryan; Joan P. Schwartz

doi:10.1016/0006-8993(88)90658-0

Morphine alters preproenkephalin gene expression

George R. Uhl, James P. Ryan, Joan P. Schwartz

School of Medicine

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Rats made tolerant/dependent to morphine by s.c. implantation of drug pellets displayed a significant decrease in striatal preproenkephalin mRNA that persisted during the period of withdrawal. Levels of Met-enkephalin were normal at the end of treatment, but reduced after withdrawal. The direction and time-course of these alterations are consistent with roles for sltered neuronal gene expression in the phenomena of opiate tolerance and dependence.

Original language	English (US)
Pages (from-to)	391-397
Number of pages	7
Journal	Brain Research
Volume	459
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)90658-0
State	Published - Sep 6 1988

Keywords

Dependence
Gene regulation
Opiate
Striatum
Tolerance

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
General Neuroscience

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AB - Rats made tolerant/dependent to morphine by s.c. implantation of drug pellets displayed a significant decrease in striatal preproenkephalin mRNA that persisted during the period of withdrawal. Levels of Met-enkephalin were normal at the end of treatment, but reduced after withdrawal. The direction and time-course of these alterations are consistent with roles for sltered neuronal gene expression in the phenomena of opiate tolerance and dependence.

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KW - Opiate

KW - Striatum

KW - Tolerance

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Morphine alters preproenkephalin gene expression

Abstract

Keywords

ASJC Scopus subject areas

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