Morphine alters preproenkephalin gene expression

George R. Uhl, James P. Ryan, Joan P. Schwartz

Research output: Contribution to journalArticlepeer-review


Rats made tolerant/dependent to morphine by s.c. implantation of drug pellets displayed a significant decrease in striatal preproenkephalin mRNA that persisted during the period of withdrawal. Levels of Met-enkephalin were normal at the end of treatment, but reduced after withdrawal. The direction and time-course of these alterations are consistent with roles for sltered neuronal gene expression in the phenomena of opiate tolerance and dependence.

Original languageEnglish (US)
Pages (from-to)391-397
Number of pages7
JournalBrain Research
Issue number2
StatePublished - Sep 6 1988


  • Dependence
  • Gene regulation
  • Opiate
  • Striatum
  • Tolerance

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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