More than scratching the surface: Mitogen receptors as transcription factors?

Daniel M. Raben, Joseph J. Baldassare

Research output: Contribution to journalReview article

Abstract

Receptor tyrosine kinases (RTK) are a large family of transmembrane receptors that stimulate several responses including differentiation, proliferation and generation of extracellular matrix. To initiate these responses, RTK activate a variety of signaling pathways at the intracellular cell surface upon binding of ligand. Recent studies demonstrate that, in addition to stimulating effectors at the plasma membrane, the C-terminal domain of the epidermal growth factor receptor and ErbB-4 receptor translocate into the nucleus. Interestingly, localization to the nucleus might be crucial to the growth response of these receptors.

Original languageEnglish (US)
Pages (from-to)93-94
Number of pages2
JournalTrends in Endocrinology and Metabolism
Volume13
Issue number3
DOIs
StatePublished - Apr 1 2002

    Fingerprint

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this