Morbid risk to first degree relatives of neuropathologically confirmed cases of alzheimer's disease

Linda M. Bierer, Jeremy M. Silverman, Richard C. Mohs, Vahram Haroutunian, Ge Lis, Dushyant Purohit, John C.S. Breitner, Daniel P. Perl, Kenneth L. Davis

Research output: Contribution to journalArticle

Abstract

One source of variance in familial aggregation studies in Alzheimer’s disease (AD) is proband diagnosis. In this study, the morbid risk of primary progressive dementia (PPD) was assessed in first degree relatives of 32 patients with clinically diagnosed AD (mean onset = 59.9 ± 7.2 years) whose diagnoses were confirmed at autopsy. The Alzheimer’s Disease Risk Questionnaire and the Dementia Questionnaire were administered to multiple family informants by trained raters blind to the probands’ clinical and ncuropathologic diagnoses. Morbid risk for PPD was analyzed using the Kaplan-Meier life-table method. The estimated cumulative risk of PPD in first degree relatives (n = 159; age ≥ 45) was estimated to be 48.8 ± 11.3% by age 86. The risk estimate for affected siblings (n = 96; age ≥ 45) reached 54.9 ± 20.7% by age 78. These figures are consistent with those calculated for most cohorts of relatives of clinically selected AD probands lacking autopsy confirmation of diagnosis. Although based on a relatively small sample, this series is the first morbid risk analysis to employ clinically diagnosed probands with ncuropathologic confirmation of AD.

Original languageEnglish (US)
Pages (from-to)134-139
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume3
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Alzheimer Disease
Dementia
Autopsy
Life Tables
Siblings
Surveys and Questionnaires

Keywords

  • Alzheimer’s disease
  • Family history
  • Genetics

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Bierer, L. M., Silverman, J. M., Mohs, R. C., Haroutunian, V., Lis, G., Purohit, D., ... Davis, K. L. (1992). Morbid risk to first degree relatives of neuropathologically confirmed cases of alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 3(3), 134-139. https://doi.org/10.1159/000107008

Morbid risk to first degree relatives of neuropathologically confirmed cases of alzheimer's disease. / Bierer, Linda M.; Silverman, Jeremy M.; Mohs, Richard C.; Haroutunian, Vahram; Lis, Ge; Purohit, Dushyant; Breitner, John C.S.; Perl, Daniel P.; Davis, Kenneth L.

In: Dementia and Geriatric Cognitive Disorders, Vol. 3, No. 3, 1992, p. 134-139.

Research output: Contribution to journalArticle

Bierer, LM, Silverman, JM, Mohs, RC, Haroutunian, V, Lis, G, Purohit, D, Breitner, JCS, Perl, DP & Davis, KL 1992, 'Morbid risk to first degree relatives of neuropathologically confirmed cases of alzheimer's disease', Dementia and Geriatric Cognitive Disorders, vol. 3, no. 3, pp. 134-139. https://doi.org/10.1159/000107008
Bierer, Linda M. ; Silverman, Jeremy M. ; Mohs, Richard C. ; Haroutunian, Vahram ; Lis, Ge ; Purohit, Dushyant ; Breitner, John C.S. ; Perl, Daniel P. ; Davis, Kenneth L. / Morbid risk to first degree relatives of neuropathologically confirmed cases of alzheimer's disease. In: Dementia and Geriatric Cognitive Disorders. 1992 ; Vol. 3, No. 3. pp. 134-139.
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