TY - JOUR
T1 - Moral Duties of Genomics Researchers
T2 - Why Personalized Medicine Requires a Collective Approach
AU - Vos, Shoko
AU - van Delden, Johannes J M
AU - van Diest, Paul J.
AU - Bredenoord, Annelien L.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Advances in genome sequencing together with the introduction of personalized medicine offer promising new avenues for research and precision treatment, particularly in the field of oncology. At the same time, the convergence of genomics, bioinformatics, and the collection of human tissues and patient data creates novel moral duties for researchers. After all, unprecedented amounts of potentially sensitive information are being generated. Over time, traditional research ethics principles aimed at protecting individual participants have become supplemented with social obligations related to the interests of society and the research enterprise at large, illustrating that genomic medicine is also a social endeavor. In this review we provide a comprehensive assembly of moral duties that have been attributed to genomics researchers and offer suggestions for responsible advancement of personalized genomic cancer care.
AB - Advances in genome sequencing together with the introduction of personalized medicine offer promising new avenues for research and precision treatment, particularly in the field of oncology. At the same time, the convergence of genomics, bioinformatics, and the collection of human tissues and patient data creates novel moral duties for researchers. After all, unprecedented amounts of potentially sensitive information are being generated. Over time, traditional research ethics principles aimed at protecting individual participants have become supplemented with social obligations related to the interests of society and the research enterprise at large, illustrating that genomic medicine is also a social endeavor. In this review we provide a comprehensive assembly of moral duties that have been attributed to genomics researchers and offer suggestions for responsible advancement of personalized genomic cancer care.
KW - cancer
KW - ethics
KW - genomics
KW - moral duties
KW - next-generation sequencing
KW - personalized medicine.
UR - http://www.scopus.com/inward/record.url?scp=85010755935&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85010755935&partnerID=8YFLogxK
U2 - 10.1016/j.tig.2016.11.006
DO - 10.1016/j.tig.2016.11.006
M3 - Review article
C2 - 28017398
AN - SCOPUS:85010755935
VL - 33
SP - 118
EP - 128
JO - Trends in Genetics
JF - Trends in Genetics
SN - 0168-9525
IS - 2
ER -