Mood, the Circadian System, and Melanopsin Retinal Ganglion Cells

Lorenzo Lazzerini Ospri, Glen Prusky, Samer Hattar

Research output: Contribution to journalArticlepeer-review


The discovery of a third type of photoreceptors in the mammalian retina, intrinsically photosensitive retinal ganglion cells (ipRGCs), has had a revolutionary impact on chronobiology. We can now properly account for numerous non-vision-related functions of light, including its effect on the circadian system. Here, we give an overview of ipRGCs and their function as it relates specifically to mood and biological rhythms. Although circadian disruptions have been traditionally hypothesized to be the mediators of light's effects on mood, here we present an alternative model that dispenses with assumptions of causality between the two phenomena and explains mood regulation by light via another ipRGC-dependent mechanism.

Original languageEnglish (US)
Pages (from-to)539-556
Number of pages18
JournalAnnual review of neuroscience
StatePublished - Jul 25 2017


  • Circadian
  • IpRGC
  • Light
  • Mood
  • Photoperiod
  • Rhythms

ASJC Scopus subject areas

  • Neuroscience(all)

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