Mood symptoms and restless legs syndrome without periodic limb movements during sleep: Is it a clinical subtype?

Hochang B. Lee, Mei Ling Song, Brian B. Koo, Yong Won Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Frequently co-occurring restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) are postulated to share common pathophysiology. The authors compared clinical characteristics and polysomnography (PSG) parameters among 155 idiopathic, untreated RLS patients who were stratified into three groups based on periodic limb movement index (PLMI). The authors found that RLS patients without PLMS (PLMI,5) had higher depression and anxiety scores, a lower total arousal index, longer latency to REM, and a higher spontaneous arousal frequency on PSG than RLS patients with PLMS. RLS severity was associated with PLMI in RLS patients with PLMS but not without PLMS. RLS without PLMS seems to be a phenotypically distinct clinical subtype of RLS. Future study should examine whether RLS without PLMS has a different clinical course, treatment response, and pathophysiology than RLS with PLMS.

Original languageEnglish (US)
Pages (from-to)52-59
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume29
Issue number1
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Mood symptoms and restless legs syndrome without periodic limb movements during sleep: Is it a clinical subtype?'. Together they form a unique fingerprint.

Cite this