Mood effects of repetitive transcranial magnetic stimulation of left prefrontal cortex in healthy volunteers

Urs P. Mosimann, Tonia A. Rihs, Judith Engeler, Hans Ulrich Fisch, Thomas E. Schlaepfer

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated the effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) of the left prefrontal cortex (LPFC) on mood in a sham-controlled crossover design. Twenty-five healthy male subjects received HF-rTMS of the LPFC in real and sham conditions. Forty trains (frequency 20 Hz, stimulation intensity 100% of individual motor threshold, train duration 2 s, intertrain interval 28 s) were applied in each session. Mood change from baseline was measured with five visual analog scales (VAS) for sadness, anxiety, happiness, tiredness and pain/discomfort. We were unable to demonstrate significant mood changes from baseline on visual analog scales after either sham or real stimulation of LPFC. There is insufficient evidence to support the general conclusion that HF-rTMS of LPFC has mood effects in healthy volunteers. Future studies should be sham-controlled, have larger sample sizes, and strictly stimulate one single region per session in order to exclude interaction effects with the previous stimulation.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalPsychiatry research
Volume94
Issue number3
DOIs
StatePublished - Jul 17 2000
Externally publishedYes

Keywords

  • Affect
  • Prefrontal cortex
  • Transcranial magnetic stimulation
  • Visual analog scales

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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