Monte Carlo fluorescence verification of experimental results for the combined ultrasonic and spectroscopic imaging of coronary artery disease

S. Warren, K. Pope, Y. Yazdi, A. Johnston, M. Davis, R. Richards-Kortum

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A system is being tested that combines fluorescence spectroscopy and intravascular ultrasound to image both chemical composition and structure of arterial tissue in vitro. In this system, distances obtained from A-mode ultrasound will be used to compensate for decreases in fluorescence intensity due to the detector-sample separation distance r. For concentrated rhodamine, a fluorescent dye, compensation has been experimentally achieved assuming fluorescence is emitted isotropically and decreases as 1/r2. For dilute rhodamine and human arterial tissue, however, compensation must be achieved with different models, since light penetration into the sample is more significant. Using optical properties consistent with those of the aforementioned samples, experimental results are successfully simulated with a Monte Carlo model for tissue fluorescence. Angular profiles are presented that demonstrate the quantitative difference between the fluorescence of these mediums. The profiles support the hypothesis that, although fluorescence is emitted isotropically within tissue, the angular distribution of light exiting the tissue is not isotropic due to reabsorption events.

Original languageEnglish (US)
Title of host publicationBiomedical Sciences Instrumentation
PublisherPubl by ISA Services Inc
Pages199-206
Number of pages8
Volume29
ISBN (Print)1556174578
StatePublished - Jan 1 1993
Externally publishedYes
EventProceedings of the 30th Annual Rocky Mountain Bioengineering Symposium and the 30th International ISA Biomedical Sciences Instrumentation Symposium - San Antonio, TX, USA
Duration: Apr 2 1993Apr 3 1993

Other

OtherProceedings of the 30th Annual Rocky Mountain Bioengineering Symposium and the 30th International ISA Biomedical Sciences Instrumentation Symposium
CitySan Antonio, TX, USA
Period4/2/934/3/93

Keywords

  • Atherosclerosis
  • Fluorescence
  • Modeling
  • Monte Carlo
  • Spectroscopy
  • Ultrasound

ASJC Scopus subject areas

  • Biophysics
  • Medical Laboratory Technology

Fingerprint Dive into the research topics of 'Monte Carlo fluorescence verification of experimental results for the combined ultrasonic and spectroscopic imaging of coronary artery disease'. Together they form a unique fingerprint.

  • Cite this

    Warren, S., Pope, K., Yazdi, Y., Johnston, A., Davis, M., & Richards-Kortum, R. (1993). Monte Carlo fluorescence verification of experimental results for the combined ultrasonic and spectroscopic imaging of coronary artery disease. In Biomedical Sciences Instrumentation (Vol. 29, pp. 199-206). Publ by ISA Services Inc.