TY - JOUR
T1 - Monozygotic co-twin analyses of body composition measurements and serum lipids
AU - Wang, Binyan
AU - Necheles, Jonathan
AU - Ouyang, Fengxiu
AU - Ma, Wei
AU - Li, Zhiping
AU - Liu, Xue
AU - Yang, Jianhua
AU - Xing, Houxun
AU - Xu, Xiping
AU - Wang, Xiaobin
N1 - Funding Information:
Supported in part by grant R01 HD049059 from the National Institute of Child Health and Development (NICHD) and R01 HL0864619 from the National Heart, Lung, Blood Institute (NHLBI).
PY - 2007/11
Y1 - 2007/11
N2 - Objective.: To evaluate BMI and direct measures of body fat (BF) and lean body mass (LBM) in relation to fasting serum lipid profiles in a large Chinese population based twin sample using a monozygotic (MZ) co-twin analysis. Methods.: Adiposity measures collected 1998-2000 on 987 MZ female 20-60 year old twin pairs (n = 1974) included BMI, waist circumference (WC), waist/hip ratio (WHR), LBM, trunk fat (TF), %TF, total BF, and % total BF (measured by DEXA). Serum lipids included total cholesterol (TC), triglycerides (TG), LDL, and HDL. Co-twin analyses and conventional regression analyses were used to assess the association between individual adiposity and LBM measures, and serum lipids. Results.: In this lean population with a mean BMI 21.8 (2.8), we observed considerable variability in adiposity measures and serum lipids. A positive linear association between all adiposity measures with LDL, TC, and TG, and a negative linear association with HDL was observed. A 1-unit z-score increase of adiposity measures, reflecting fat distribution, was associated with increases in (mmol/L) TC (0.063 to 0.164), LDL (0.064 to 0.131), TG (0.049 to 0.164), and a decrease in HDL (0.021 to 0.038) while controlling for matched factors within twin pairs (i.e., age and unmeasured confounders). However, similar associations were not observed for LBM. Conclusion.: It is the BF (not LBM) that appears to be associated with serum lipid profiles. This study underscores that in populations where BMI is highly correlated with BF, BMI can be used as a surrogate for BF in evaluating risk of dyslipidemia. Otherwise, direct measures of BF are needed.
AB - Objective.: To evaluate BMI and direct measures of body fat (BF) and lean body mass (LBM) in relation to fasting serum lipid profiles in a large Chinese population based twin sample using a monozygotic (MZ) co-twin analysis. Methods.: Adiposity measures collected 1998-2000 on 987 MZ female 20-60 year old twin pairs (n = 1974) included BMI, waist circumference (WC), waist/hip ratio (WHR), LBM, trunk fat (TF), %TF, total BF, and % total BF (measured by DEXA). Serum lipids included total cholesterol (TC), triglycerides (TG), LDL, and HDL. Co-twin analyses and conventional regression analyses were used to assess the association between individual adiposity and LBM measures, and serum lipids. Results.: In this lean population with a mean BMI 21.8 (2.8), we observed considerable variability in adiposity measures and serum lipids. A positive linear association between all adiposity measures with LDL, TC, and TG, and a negative linear association with HDL was observed. A 1-unit z-score increase of adiposity measures, reflecting fat distribution, was associated with increases in (mmol/L) TC (0.063 to 0.164), LDL (0.064 to 0.131), TG (0.049 to 0.164), and a decrease in HDL (0.021 to 0.038) while controlling for matched factors within twin pairs (i.e., age and unmeasured confounders). However, similar associations were not observed for LBM. Conclusion.: It is the BF (not LBM) that appears to be associated with serum lipid profiles. This study underscores that in populations where BMI is highly correlated with BF, BMI can be used as a surrogate for BF in evaluating risk of dyslipidemia. Otherwise, direct measures of BF are needed.
KW - Body fat
KW - Body mass index
KW - Chinese
KW - Lean body mass
KW - Monozygotic twins
KW - Obesity
KW - Serum lipids
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U2 - 10.1016/j.ypmed.2007.07.014
DO - 10.1016/j.ypmed.2007.07.014
M3 - Article
C2 - 17765960
AN - SCOPUS:35748946319
SN - 0091-7435
VL - 45
SP - 358
EP - 365
JO - Preventive Medicine
JF - Preventive Medicine
IS - 5
ER -