TY - JOUR
T1 - Monophasic autoimmune inflammatory diseases of the CNS and PNS.
AU - Griffin, D. E.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 1990
Y1 - 1990
N2 - Post-rabies vaccine encephalomyelitis, postinfectious encephalomyelitis, and acute inflammatory demyelinating polyneuropathy are all monophasic, inflammatory, demyelinating diseases that appear to be autoimmune in pathogenesis and induced by prior antigenic stimulation or infection. The primary encephalitogen for rabies vaccine and postinfectious encephalomyelitis appears to be MBP, with a possible augmenting role for the myelin glycolipids. The primary neuritogen in AIDP may be a glycolipid, but this has not been clearly established. The mechanism by which a prior, apparently unrelated, stimulus leads to postinfectious encephalomyelitis or AIDP is unclear, but abnormalities of immune regulation, possible molecular mimicry between infectious agents and neural constituents, and genetic susceptibility may each play important roles (Table 1).
AB - Post-rabies vaccine encephalomyelitis, postinfectious encephalomyelitis, and acute inflammatory demyelinating polyneuropathy are all monophasic, inflammatory, demyelinating diseases that appear to be autoimmune in pathogenesis and induced by prior antigenic stimulation or infection. The primary encephalitogen for rabies vaccine and postinfectious encephalomyelitis appears to be MBP, with a possible augmenting role for the myelin glycolipids. The primary neuritogen in AIDP may be a glycolipid, but this has not been clearly established. The mechanism by which a prior, apparently unrelated, stimulus leads to postinfectious encephalomyelitis or AIDP is unclear, but abnormalities of immune regulation, possible molecular mimicry between infectious agents and neural constituents, and genetic susceptibility may each play important roles (Table 1).
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M3 - Review article
C2 - 1970192
AN - SCOPUS:0025032923
SN - 0091-7443
VL - 68
SP - 91
EP - 104
JO - Research publications - Association for Research in Nervous and Mental Disease
JF - Research publications - Association for Research in Nervous and Mental Disease
ER -