TY - JOUR
T1 - Monomorphic post-transplant lymphoproliferative disorder of the tongue
T2 - Case report and review of literature
AU - Gonzalez-Cuyar, Luis F.
AU - Tavora, Fabio
AU - Burke, Allen P.
AU - Gocke, Christopher D.
AU - Zimrin, Ann
AU - Sauk, John J.
AU - Zhao, Xiafeng F.
PY - 2007
Y1 - 2007
N2 - Background. Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of hematological diseases arising in context of immunosuppression after organ transplantation. PTLD can involve any organ; however, it is extremely rare in oral cavity. Methods. Using morphologic and immunophenotypic approaches we have studied a case of monomorphic PTLD of the tongue that developed in a patient following unilateral kidney and pancreas transplantation on immunosuppressive therapy. Additionally, cases of PTLD in the oral cavity were reviewed in the English literature. Results. The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridization for Epstein-Barr virus was positive. Complete remission was obtained after decreasing immunosuppressive therapy. The patient remained in remission at 790 days' follow up. Conclusion. This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.
AB - Background. Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of hematological diseases arising in context of immunosuppression after organ transplantation. PTLD can involve any organ; however, it is extremely rare in oral cavity. Methods. Using morphologic and immunophenotypic approaches we have studied a case of monomorphic PTLD of the tongue that developed in a patient following unilateral kidney and pancreas transplantation on immunosuppressive therapy. Additionally, cases of PTLD in the oral cavity were reviewed in the English literature. Results. The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridization for Epstein-Barr virus was positive. Complete remission was obtained after decreasing immunosuppressive therapy. The patient remained in remission at 790 days' follow up. Conclusion. This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.
UR - http://www.scopus.com/inward/record.url?scp=38949139120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38949139120&partnerID=8YFLogxK
U2 - 10.1186/1746-1596-2-49
DO - 10.1186/1746-1596-2-49
M3 - Article
AN - SCOPUS:38949139120
SN - 1746-1596
VL - 2
JO - Diagnostic Pathology
JF - Diagnostic Pathology
IS - 1
M1 - 49
ER -