TY - JOUR
T1 - Monoexponential, biexponential, and stretched exponential diffusion-weighted imaging models
T2 - Quantitative biomarkers for differentiating renal clear cell carcinoma and minimal fat angiomyolipoma
AU - Li, Haojie
AU - Liang, Lili
AU - Li, Anqin
AU - Hu, Yao
AU - Hu, Daoyu
AU - Li, Zhen
AU - Kamel, Ihab R.
N1 - Funding Information:
Contract grant sponsor: National Natural Science Foundation of China; contract grant number: 81271529; Contract grant number: 81371524
Publisher Copyright:
© 2016 International Society for Magnetic Resonance in Medicine
PY - 2017/7
Y1 - 2017/7
N2 - Purpose: To determine the utility of various diffusion parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging (DWI) models in differentiating between minimal fat angiomyolipoma (MFAML) and clear cell renal cell carcinoma (ccRCC). Materials and Methods: One hundred thirty-one patients with pathologically confirmed MFAML (n = 27) or ccRCC (n = 104) underwent multi-b value DWI (0∼1700 s/mm2) imaging at 3.0 Tesla MRI. An isotropic apparent diffusion coefficient (ADC) was calculated from diffusion-weighted images by using a monoexponential model. A pseudo-ADC (Dp), true ADC (Dt), and perfusion fraction (fp) were calculated from diffusion-weighted images by using a biexponential model. A water molecular diffusion heterogeneity index (α) and distributed diffusion coefficient (DDC) were calculated from diffusion-weighted images by using a stretched exponential model. All parameters were compared between MFAML and ccRCC by using the Student's t test. Receiver operating characteristic and intraclass correlation coefficient analysis were used for statistical evaluations. Results: ADC, Dt, and α values were significantly lower in the MFAML group than in the ccRCC group (P < 0.001). Dp, fp, and DDC values were slightly higher in the MFAML group than in the ccRCC group; however, the difference was not significant (P = 0.136, 0.090, and 0.424, respectively). The AUC values for both α (0.953) and Dt (0.964) were significantly higher than those for ADC (0860), Dp (0.605), fp (0.596), and DDC (0.477) in the differentiation of MFAML from ccRCC (P < 0.001). Conclusion: Water molecular diffusion heterogeneity index (α) and Dt may provide additional information and could lead to improved differentiation with better sensitivity and specificity between MFAML and ccRCC compared with conventional diffusion parameters. Level of Evidence: 3. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:240–247.
AB - Purpose: To determine the utility of various diffusion parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging (DWI) models in differentiating between minimal fat angiomyolipoma (MFAML) and clear cell renal cell carcinoma (ccRCC). Materials and Methods: One hundred thirty-one patients with pathologically confirmed MFAML (n = 27) or ccRCC (n = 104) underwent multi-b value DWI (0∼1700 s/mm2) imaging at 3.0 Tesla MRI. An isotropic apparent diffusion coefficient (ADC) was calculated from diffusion-weighted images by using a monoexponential model. A pseudo-ADC (Dp), true ADC (Dt), and perfusion fraction (fp) were calculated from diffusion-weighted images by using a biexponential model. A water molecular diffusion heterogeneity index (α) and distributed diffusion coefficient (DDC) were calculated from diffusion-weighted images by using a stretched exponential model. All parameters were compared between MFAML and ccRCC by using the Student's t test. Receiver operating characteristic and intraclass correlation coefficient analysis were used for statistical evaluations. Results: ADC, Dt, and α values were significantly lower in the MFAML group than in the ccRCC group (P < 0.001). Dp, fp, and DDC values were slightly higher in the MFAML group than in the ccRCC group; however, the difference was not significant (P = 0.136, 0.090, and 0.424, respectively). The AUC values for both α (0.953) and Dt (0.964) were significantly higher than those for ADC (0860), Dp (0.605), fp (0.596), and DDC (0.477) in the differentiation of MFAML from ccRCC (P < 0.001). Conclusion: Water molecular diffusion heterogeneity index (α) and Dt may provide additional information and could lead to improved differentiation with better sensitivity and specificity between MFAML and ccRCC compared with conventional diffusion parameters. Level of Evidence: 3. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:240–247.
KW - angiomyolipoma
KW - clear cell renal cell carcinoma
KW - diffusion-weighted imaging
KW - exponential models
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U2 - 10.1002/jmri.25524
DO - 10.1002/jmri.25524
M3 - Article
C2 - 27859853
AN - SCOPUS:85000460165
SN - 1053-1807
VL - 46
SP - 240
EP - 247
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 1
ER -